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Present and future treatment strategies for coronavirus disease 2019

Engy Elekhnawy1, Amal Abo Kamar1, Fatma Sonbol1

  • 1Pharmaceutical Microbiology, Faculty of Pharmacy, Tanta University, Tanta, El Gharbia Governorate Egypt.

Future Journal of Pharmaceutical Sciences
|April 14, 2021
PubMed
Abstract

Insights

This review explores drug repurposing for COVID-19 treatment, summarizing potential therapies like remdesivir and hydroxychloroquine. It also discusses future strategies based on new genomic discoveries for managing the pandemic.

Area of Science:

  • Virology
  • Pharmacology
  • Genomics

Background:

  • The coronavirus disease 2019 (COVID-19) pandemic has presented significant global healthcare challenges.
  • Currently, no definitively effective therapeutic agents are established for treating COVID-19.

Purpose of the Study:

  • To review and summarize potential drug repurposing candidates for COVID-19 treatment.
  • To discuss emerging therapeutic strategies informed by molecular and genomic advancements.

Main Methods:

  • Literature review of evolving studies on drug repurposing for COVID-19.
  • Identification and summarization of drugs with proposed pharmacological and therapeutic effects against SARS-CoV-2.
  • Analysis of recent molecular and genomic discoveries for future treatment planning.

Main Results:

  • Identified numerous drugs for potential repurposing, including lopinavir-ritonavir, ribavirin, favipiravir, remdesivir, chloroquine, hydroxychloroquine, azithromycin, corticosteroids, and others.
  • Highlighted the need for evidence-based therapeutic strategies.
  • Acknowledged the ongoing search for effective COVID-19 treatments.

Conclusions:

  • The review provides valuable insights into current and potential future treatment options for COVID-19.
  • Drug repurposing offers a promising avenue for managing the pandemic.
  • Further research into molecular and genomic data is crucial for developing advanced therapeutic regimens.
Keywords:
COVID-19Cytokine stormRespiratory distress syndromeSARS-Cov-2

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