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Related Experiment Videos

Folate nutriture in pregnancy.

A M Huber1, L L Wallins, P DeRusso

  • 1Department of Nutrition, Simmons College, Boston.

Journal of the American Dietetic Association
|July 1, 1988
PubMed
Summary
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Maternal folate intake during pregnancy, from diet and supplements, impacts folate levels in mothers and newborns. High supplement use may pose risks due to potential nutrient interactions.

Area of Science:

  • Nutritional Science
  • Maternal and Child Health
  • Biochemistry

Background:

  • Adequate folacin (folate) intake is crucial during pregnancy for maternal and fetal health.
  • Dietary sources and supplements are common methods for increasing folate consumption.
  • Understanding the relationship between intake and blood levels is essential for assessing nutritional status.

Purpose of the Study:

  • To determine folacin intake from diet and supplements in pregnant women.
  • To correlate maternal and cord blood folate levels with folacin intake.
  • To investigate potential risks associated with high folate supplement consumption.

Main Methods:

  • Interview-based assessment of folacin intake in 566 pregnant women.
  • Analysis of serum and erythrocyte folate levels in maternal and cord blood samples.

Related Experiment Videos

  • Statistical correlation between reported folacin intake and measured folate levels.

    • Main Results:

    • 8% of women consumed folate from diet only; 13% had intake below two-thirds of the RDA.
    • Women with diet-only folate intake exhibited marginal to deficient maternal serum folate levels.
    • Significant correlations were found between total folacin intake and maternal/cord folate levels, with some exceeding the RDA eightfold via supplements.

    Conclusions:

    • Dietary folate alone may be insufficient for some pregnant women.
    • High folate intake from supplements is common and significantly correlates with elevated maternal and cord blood folate levels.
    • Excessive folate from supplements raises concerns regarding potential adverse interactions with other nutrients.