Related Experiment Video
Updated: Nov 9, 2025
07:13
Two Techniques to Create Hypoparathyroid Mice: Parathyroidectomy Using GFP Glands and Diphtheria-Toxin-Mediated Parathyroid Ablation
Published on: March 14, 2017
14.9K
Myelofibrosis and Pancytopenia Associated With Primary Hyperparathyroidism
Remya Rajan1, Immanuel Paul2, Kripa Elizabeth Cherian1
1Department of Endocrinology, Diabetes and Metabolism, Christian Medical College and Hospital, Vellore, India.
AACE Clinical Case Reports
|April 14, 2021
Summary
Primary hyperparathyroidism (PHPT) can rarely cause pancytopenia. Evaluating calcium levels is crucial for patients with unexplained low blood counts.
Area of Science:
- Endocrinology
- Hematology
- Oncology
Background:
- Primary hyperparathyroidism (PHPT) typically presents with varied symptoms, but hematologic abnormalities are less common.
- Pancytopenia, a significant reduction in all blood cell types, is a rare initial manifestation of PHPT.
Observation:
- A 48-year-old woman presented with severe pancytopenia and bone marrow fibrosis.
- Biochemical tests revealed hypercalcemia, hypophosphatemia, and elevated alkaline phosphatase, indicative of PHPT.
- Bone density scans showed osteoporosis.
Findings:
- The patient was diagnosed with PHPT (serum parathyroid hormone: 2082 pg/mL).
- Following parathyroidectomy, her calcium levels normalized, and hematologic parameters (hemoglobin, white blood cells, platelets) fully recovered within three months.
Implications:
- Pancytopenia can be an unusual presentation of PHPT.
- Calcium profiling should be considered in patients with refractory anemia and pancytopenia to rule out PHPT.
Related Concept Videos
01:24Chronic Kidney Disease II: Clinical Manifestations
255
Chronic Kidney Disease (CKD) progressively impairs multiple body systems due to the accumulation of uremic toxins, which disrupt cellular functions across various organs.Neurologic symptomsNeurologic symptoms often arise early in CKD, as uremic toxin buildup drives changes in cognitive and motor functions. Patients frequently experience fatigue, headache, confusion, difficulty concentrating, and, in severe cases, seizures. Peripheral neuropathy commonly manifests as burning sensations in the...
255
00:59The Parathyroid Glands
3.3K
The two pairs of parathyroid glands embedded within the posterior surface of the thyroid gland are restricted by a dense capsule around them. These glands comprise two distinct cell populations—parathyroid oxyphil and parathyroid principal cells- pivotal in calcium homeostasis.
Oxyphil cells, whose functions remain elusive, emerge during late puberty, adding a layer of complexity to the parathyroid gland's intricacies. In contrast, principal parathyroid cells undertake a vital role by...
Oxyphil cells, whose functions remain elusive, emerge during late puberty, adding a layer of complexity to the parathyroid gland's intricacies. In contrast, principal parathyroid cells undertake a vital role by...
3.3K
01:17Hormones and Bone Tissue
3.3K
The endocrine system produces and secretes hormones, which interact with the skeletal system. These hormones control bone growth, maintain bone once it is formed, and remodel it.
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
3.3K
01:27Disorders of Erythrocytes
1.7K
Disorders of erythrocytes, or red blood cells (RBCs), include a range of conditions affecting their number, shape, or function.
Erythrocyte disorders can be broadly categorized into two main types: anemic and polycythemic conditions.
A low oxygen-carrying capacity of the blood due to the loss, lower production, or destruction of erythrocytes is termed anemia. Hemorrhagic anemia, for example, occurs when bleeding from an external wound or internal ulcer reduces erythrocyte counts.
On the other...
Erythrocyte disorders can be broadly categorized into two main types: anemic and polycythemic conditions.
A low oxygen-carrying capacity of the blood due to the loss, lower production, or destruction of erythrocytes is termed anemia. Hemorrhagic anemia, for example, occurs when bleeding from an external wound or internal ulcer reduces erythrocyte counts.
On the other...
1.7K
01:27Roles of Electrolytes: Calcium and Phosphate
826
Calcium and phosphate are essential electrolytes in the human body, with calcium being the most abundant mineral. Around 99% of the body's calcium is stored in the skeleton and teeth, forming a crystal lattice of mineral salts in combination with phosphates. Calcium plays crucial roles in various bodily functions such as blood clotting, neurotransmitter release, muscle tone maintenance, and nervous and muscle tissue excitability.
The calcium concentration in blood plasma is primarily...
The calcium concentration in blood plasma is primarily...
826
01:21Skeleton and Calcium Homeostasis
5.3K
Calcium is not only the most abundant mineral in bone but also the most abundant mineral in the human body. Calcium ions are needed for bone mineralization, tooth health, heart rate regulation and strength of contraction, blood coagulation, the contraction of smooth and skeletal muscle cells, and the regulation of nerve impulse conduction. The average calcium level in the blood is about 10 mg/dL. When the body cannot maintain this level, a person will experience hypo or hypercalcemia.
5.3K