The evaluation of relationship between polypharmacy and anticholinergic burden scales
Saadet Koc Okudur1, Ozge Dokuzlar2, Ali Ekrem Aydin3
1Department of Geriatric Medicine, Manisa State Hospital, Manisa, Turkey.
Objective:
Polypharmacy and anticholinergic burden are the indicators for the evaluation of the quality of pharmacotherapy in older adults. The aim of this study was to consider which anticholinergic burden scales are more related with polypharmacy among older patients.
Methods:
Four hundred and twenty older adults were evaluated retrospectively in this cross-sectional study. The patient's demographic data, comorbidities, the drugs, and number of drugs were recorded. Anticholinergic burden scales were calculated by a tool named anticholinergic burden calculator.
Results:
The participants' mean age was 73.08±8.71. The prevalence of polypharmacy was 32.14%. The highest relationship with polypharmacy was observed for drug burden index (DBI) (odds ratio 10.87, p<0.001).
Conclusion:
Our study demonstrated that polypharmacy and DBI scores were more related than other anticholinergic burden scales in older adults.
Related Concept Videos
Drug Dosing: Geriatric Patients
Drug Therapy
Antianxiety Medications
Effect of Hepatic Disease on Pharmacokinetics: Dose Adjustments Due to Hepatic Impairment
Nonlinear Pharmacokinetics: Dependence of Elimination Half-Life and Dose Clearance
A study on guinea pigs examined the...
Pharmacodynamics in Geriatric Patients: Effects of Age
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Excretion


