Related Experiment Video
Updated: Nov 9, 2025
08:07
A Morphometric and Cellular Analysis Method for the Murine Mandibular Condyle
Published on: January 11, 2018
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Quantitative assessment of age-related changes in the mandibular bone marrow using apparent coefficient value
Hirotaka Muraoka1, Kotaro Ito2, Naohisa Hirahara2
1Department of Radiology, Nihon University School of Dentistry At Matsudo, 2-870-1 Sakaecho-Nishi, Matsudo, Chiba, 271-8587, Japan. muraoka.hirotaka@nihon-u.ac.jp.
Oral Radiology
|April 14, 2021
Summary
Apparent diffusion coefficient (ADC) values in mandibular bone marrow decrease with age in both men and women. This age-related change in ADC values is significant and can aid in diagnosing bone marrow diseases.
Area of Science:
- Radiology
- Biomedical Imaging
- Bone Marrow Imaging
Background:
- Age-related changes in bone marrow composition are not fully understood.
- Diffusion-weighted imaging (DWI) offers a non-invasive method to assess tissue microstructure.
Purpose of the Study:
- To investigate age-related changes in apparent diffusion coefficient (ADC) values of mandibular bone marrow.
- To establish normative ADC values for different age groups.
Main Methods:
- Retrospective cohort study of 351 participants (15-89 years) who underwent pantomography and MRI.
- Analysis of apparent diffusion coefficient (ADC) values using diffusion-weighted imaging (DWI).
- Spearman's correlation coefficients were used to assess the relationship between age and ADC values.
Main Results:
- Mean ADC values were 0.91±0.18 in men and 0.86±0.16 in women.
- A significant negative correlation was found between age and ADC values in both sexes (p<0.001).
Conclusions:
- Mandibular bone marrow ADC values significantly decrease with increasing age.
- These findings provide valuable reference data for diagnosing bone marrow diseases.
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