Can we treat inflammation by managing misbehaving monocytes?
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Updated: Nov 9, 2025

Quantification of Monocyte Chemotactic Activity In Vivo and Characterization of Blood Monocyte Derived Macrophages
Published on: August 12, 2019
1Institute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow, UK.
Abstract:
When monocytes migrate from blood into tissues they differentiate into macrophage-like cells. The outcome of this differentiation process is strongly influenced by the tissue environment, and the macrophages produced help control the immunological properties of the tissue. The process of monocyte-macrophage differentiation is therefore potentially attractive when seeking therapeutic targets to amplify or modulate the inflammatory response. Here we highlight recent research in this area, identifying the gene Paqr11 as an important factor in monocyte differentiation, and therefore an important potential target for reducing macrophage-mediated inflammation in arthritis.
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