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Updated: Nov 9, 2025

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Published on: January 2, 2015
Roles and mechanisms of phospholipid transfer protein in the development of Alzheimer's disease
Hao Wang1, Mei-Hua Chen1, Wei Chen1
1Institute of Pharmacology, Shandong First Medical University and Shandong Academy of Medical Sciences, Tai'an, China.
Abstract:
Phospholipid transfer protein (PLTP) is a complex glycosylated protein that mediates the transfer of phospholipids, unesterified cholesterol, diacylglycerides, specific apolipoproteins, and tocopherols between different classes of lipoproteins as well as between lipoproteins and cells. Many studies have associated PLTP with a variety of lipid metabolic diseases. However, recent studies have indicated that PLTP is highly expressed in the brain of vertebrate and may be related to many central nervous system diseases, such as Alzheimer's disease. Here, we review the data and report the role and mechanisms PLTP in Alzheimer's disease.
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