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Related Experiment Video

Updated: Nov 9, 2025

In Vitro Selection of Aptamers to Differentiate Infectious from Non-Infectious Viruses
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Aptamers: The Powerful Molecular Tools for Virus Detection.

Cong Han1, Qian Li2, Haishuo Ji2

  • 1State Key Laboratory of Medicinal Chemical biology, College of Life Sciences, Nankai University, Tianjin, 300350, P. R. China.

Chemistry, an Asian Journal
|April 14, 2021
PubMed
Summary

Aptasensors, or aptamer-based sensors, offer a novel approach for detecting viruses. This review highlights their potential for portable, point-of-care COVID-19 testing using smartphones.

Keywords:
AptamerAptasensorsCOVID-19Point-of-care TestVirus detection

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Area of Science:

  • Biotechnology
  • Biosensors
  • Nucleic Acid Chemistry

Background:

  • Aptamers are single-stranded DNA or RNA oligonucleotides selected via SELEX, functioning as "chemical antibodies" due to their target-binding capabilities.
  • Aptamers can bind a wide range of targets, including small molecules, cells, and tissues.
  • The development of aptamer-based sensors (aptasensors) has shown promise for various diagnostic applications.

Purpose of the Study:

  • To review and evaluate recent advancements in aptasensor technology for virus detection.
  • To explore the classification of aptasensors based on their transducer types (optical and electronic).
  • To emphasize the future importance of smartphone-based aptasensors for portable, point-of-care testing, particularly for COVID-19.

Main Methods:

  • Systematic evolution of ligands by exponential enrichment (SELEX) for aptamer selection.
  • Classification of aptasensors into optical and electronic types based on transducer technology.
  • Review of literature on aptasensor applications in virus detection.

Main Results:

  • Aptasensors demonstrate versatility in detecting various targets, analogous to antibodies.
  • Optical and electronic aptasensors represent key categories in virus detection technology.
  • The integration of aptasensors with smartphones offers a pathway for accessible diagnostics.

Conclusions:

  • Aptasensors are highly promising tools for sensitive and specific virus detection.
  • Smartphone-based aptasensors are poised to revolutionize point-of-care diagnostics, especially in the context of global health crises like COVID-19.
  • Further development in aptasensor technology will enhance their utility in portable and rapid diagnostic platforms.