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Related Experiment Videos

Interstitial thermoradiotherapy for recurrent or persistent tumours.

K Lam1, M Astrahan, B Langholz

  • 1Department of Radiation Oncology, University of Southern California School of Medicine, Los Angeles 90033.

International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group
|May 1, 1988
PubMed
Summary

Combining radiation therapy (RT) with interstitial microwave hyperthermia (HT) effectively treats recurrent tumors. This approach achieved a high complete response rate, demonstrating its efficacy in managing challenging cancer cases.

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Area of Science:

  • Oncology
  • Radiation Oncology
  • Medical Physics

Background:

  • Recurrent tumors present a significant clinical challenge, often requiring multimodal treatment strategies.
  • Previous treatments like surgery, radiation therapy (RT), or chemotherapy may have been ineffective or led to recurrence.

Purpose of the Study:

  • To evaluate the effectiveness of combining interstitial microwave hyperthermia (HT) with iridium-192 brachytherapy (RT) for treating biopsy-proven recurrent tumors.
  • To assess treatment response rates, tumor control, and complications associated with this combined modality therapy.

Main Methods:

  • A cohort of 27 patients with 31 tumor sites received interstitial microwave hyperthermia (HT) combined with iridium-192 implants (RT) between 1984 and 1986.
  • Tumor sites included head and neck, breast, vagina, cervix, and others, with all patients having received prior treatments.

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  • Response was assessed based on complete response (CR) and partial response (PR), with follow-up to monitor recurrence and survival.

    • Main Results:

    • A complete response (CR) was observed in 19 out of 31 treated sites (61%), with no recurrence within the treated volume.
    • Eight patients remained tumor-free for 3 to 24 months.
    • Partial response (PR) occurred in 11 sites (36%), and one site showed lesser tumor regression (3%).
    • Tumor control correlated significantly with radiation dose (p=0.02) and tumor volume (p=0.02), but not with thermal dose.
    • A single significant complication (3%) of soft tissue necrosis was reported.

    Conclusions:

    • The combination of radiation therapy (RT) and interstitial microwave hyperthermia (HT) is an effective treatment for recurrent tumors.
    • This multimodal approach demonstrates a high rate of tumor control and complete response, offering a viable option for patients with previously treated malignancies.
    • Further research may optimize thermal dose parameters to potentially improve outcomes and minimize complications.