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Antibiotic Selection

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Updated: Nov 9, 2025

Antimicrobial Peptides Produced by Selective Pressure Incorporation of Non-canonical Amino Acids

Antimicrobial Peptides Produced by Selective Pressure Incorporation of Non-canonical Amino Acids

Published on: May 4, 2018

Engineering Selectively Targeting Antimicrobial Peptides.

Ming Lei¹, Arul Jayaraman^2,3, James A Van Deventer^1,4

¹Department of Chemical and Biological Engineering, Tufts University, Medford, Massachusetts 02155, USA; email: ming.lei@tufts.edu, James.Van_Deventer@tufts.edu, kyongbum.lee@tufts.edu.

Annual Review of Biomedical Engineering

|April 14, 2021

Summary

This summary is machine-generated.

Developing new therapeutics is crucial due to rising antibiotic resistance. Antimicrobial peptides (AMPs) show promise, but designing selective AMPs to target specific bacteria remains a challenge.

Keywords:

antimicrobial peptides cell selectivity high-throughput screening machine learning microbiota peptide conjugates

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Production and Visualization of Bacterial Spheroplasts and Protoplasts to Characterize Antimicrobial Peptide Localization

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Production and Visualization of Bacterial Spheroplasts and Protoplasts to Characterize Antimicrobial Peptide Localization

Production and Visualization of Bacterial Spheroplasts and Protoplasts to Characterize Antimicrobial Peptide Localization

Published on: August 11, 2018

Area of Science:

Microbiology
Biochemistry
Drug Discovery

Background:

Antibiotic resistance necessitates novel therapeutic strategies.
Antimicrobial peptides (AMPs) offer potential as targeted antibacterial agents.
AMPs exhibit diverse structures and functions, amenable to enhancement.

Purpose of the Study:

To review molecular mechanisms of AMP selectivity.
To highlight efforts in designing selectively targeting AMPs.
To discuss challenges and strategies for AMP development.

Main Methods:

Review of computational and experimental design strategies for AMPs.
Analysis of molecular mechanisms governing AMP-bacterial interactions.
Examination of methods for assaying AMP activity and selectivity.

Main Results:

Significant efforts exist to discover potent AMPs.
Designing AMPs for selective bacterial targeting based on physicochemical properties is challenging.
Diverse approaches can enhance AMP structural and functional diversity.

Conclusions:

Further research is needed to overcome challenges in selective AMP design.
Chemical modifications and advanced screening can increase AMP diversity.
Understanding AMP selectivity mechanisms is key for developing next-generation antibiotics.