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Methods for Evaluating the Role of c-Fos and Dusp1 in Oncogene Dependence
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Duality of glucocorticoid action in cancer: tumor-suppressor or oncogene?

Isabel Mayayo-Peralta1, Wilbert Zwart1,2, Stefan Prekovic1

  • 1Division of Oncogenomics, Oncode Institute, the Netherlands Cancer Institute, Amsterdam, the Netherlands.

Endocrine-Related Cancer
|April 14, 2021
PubMed

Insights

Glucocorticoid receptor (GR) regulates bodily functions and impacts cancer. This review explores GR's molecular role in solid tumors, affecting disease progression and drug resistance.

Area of Science:

  • Molecular Biology
  • Oncology
  • Endocrinology

Background:

  • Glucocorticoid receptor (GR) is vital for homeostasis, influencing immune, metabolic, and lung functions.
  • GR signaling is implicated in various diseases, notably cancer.
  • While GR activation treats liquid cancers, its role in solid tumors is complex and cancer-specific.

Purpose of the Study:

  • To review the molecular mechanisms of Glucocorticoid receptor (GR) action in cancer.
  • To elucidate GR's role in the development, progression, and drug resistance of solid tumors.

Main Methods:

  • Literature review focusing on molecular and cellular biology of GR.
  • Analysis of GR's structural and functional aspects in relation to glucocorticoid response.
  • Examination of GR's involvement in diverse solid cancer types.

Main Results:

  • GR's dual role in cancer: context-dependent effects on tumorigenesis.
  • GR influences cancer cell proliferation, apoptosis, and immune evasion.
  • GR signaling impacts therapeutic responses and resistance mechanisms in solid tumors.

Conclusions:

  • Understanding GR's molecular biology is crucial for targeted cancer therapies.
  • GR's complex role necessitates cancer-type-specific therapeutic strategies.
  • Further research into GR pathways can reveal novel targets for solid tumor treatment.
Keywords:
cancerglucocorticoid receptorglucocorticoidsnuclear receptortranscriptional regulation

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