Retrospective Cohort Noninferiority Analysis of Barrier Cream in Preventing Pressure Injuries
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Rafael Garcia-Carretero1, María-Vicenta Ballesteros-Ubeda, Ana Martínez-Alvarez
1At the University Hospital of Móstoles, Madrid, Spain, Rafael Garcia-Carretero, MD, PhD, is Senior Internal Medicine Physician; María-Vicenta Ballesteros-Ubeda, RN, is Nurse Midwife; Ana Martínez-Alvarez, RN, is Critical Care Nurse; and María-Lara Martinez-Gimeno, RN, is Perioperative Nurse. The authors have disclosed no financial relationships related to this article. Submitted May 31, 2020; accepted in revised form July 13, 2020.
Objective:
To assess the effectiveness of a dimethicone- and zinc-based barrier cream compared with hyperoxygenated fatty acids in preventing pressure injuries (PIs) in patients at high or very high risk.
Methods:
Researchers conducted a retrospective noninferiority study in an inpatient acute care hospital in Spain that included hospitalized patients in nonsurgical departments with impaired mobility.
Results:
The study authors reviewed 522 patients in a control group (hyperoxygenated fatty acids) and an experimental group (barrier cream) over a period of 7 days. The incidence of PI was 31% in the control group and 31.1% in the experimental group. The hazard ratio for developing PI was 0.84 (confidence interval, 0.61-1.17; P = .32) in the experimental group compared with the control group, meeting the criteria for noninferiority. The Kaplan-Meier estimator indicated no statistically significant difference between groups (log-rank = 0.654).
Conclusions:
Dimethicone- and zinc-based barrier cream was not inferior to hyperoxygenated fatty acids in preventing PIs in hospitalized patients at high or very high risk of developing them during their hospital stay.
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