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Updated: Nov 9, 2025
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Stimulation of Cytoplasmic DNA Sensing Pathways In Vitro and In Vivo
Published on: September 18, 2014
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A "KU" new sensor for cytosolic DNA in T cells
1Department of Immunology, University of Texas Southwestern Medical School, Dallas, TX, USA.
Immunity
|April 14, 2021
Abstract:
Adaptive immune cells are usually not equipped with pattern recognition receptors. In this issue of Immunity, Wang et al. revealed an "innate-like" cytosolic DNA-sensing mechanism by the KU complex in aged CD4+ T cells, which exacerbates aging-related autoimmunity.
