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In Vitro Thrombosis Test for Ventricular Assist Devices

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In vitro diagnostics for the medical dermatologist. Part II: Hypercoagulability tests.

Kelsey B Nusbaum¹, Abraham M Korman², Kelly H Tyler²

¹University of Cincinnati College of Medicine, Cincinnati, Ohio.

Journal of the American Academy of Dermatology

|April 14, 2021

Summary

This summary is machine-generated.

Skin findings like livedo reticularis can indicate hypercoagulability, necessitating specific lab tests. Proper test selection and interpretation are crucial for accurate diagnosis and management of these thrombotic disorders.

Keywords:

D-dimer antiphospholipid antibodies cryofibrinogenemia cryoglobulinemia diagnostic testing factor deficiency genetic thrombophilia hereditary thrombophilia hypercoagulability medical dermatology monoclonal gammopathy multiple myeloma pyoderma gangrenosum retiform purpura thrombogenic vasculopathy thrombotic vasculopathy ulcer

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Area of Science:

Dermatology
Hematology
Clinical Pathology

Background:

Cutaneous manifestations such as livedo reticularis and purpura can be early indicators of hypercoagulability.
These skin findings are nonspecific and often require laboratory testing to identify underlying causes.
Hypercoagulability disorders are frequently misdiagnosed as pyoderma gangrenosum.

Purpose of the Study:

To review the methodology, characteristics, and limitations of in vitro laboratory tests for hypercoagulability.
To guide appropriate test ordering and interpretation in dermatologic conditions.
To improve the diagnosis and management of hypercoagulability and vasculopathic disease.

Main Methods:

Review of in vitro laboratory tests for hypercoagulability and vasculopathic disease.
Summary of test characteristics, including methodology and limitations.
Focus on relevance to dermatologic manifestations and diagnosis.

Main Results:

Understanding test properties is essential for accurate diagnosis.
Indiscriminate test ordering can lead to inaccurate results and management challenges.
This article provides a summary of key laboratory tests for hypercoagulability workup.

Conclusions:

Appropriate laboratory test selection and interpretation are vital for diagnosing hypercoagulability in patients with skin findings.
Accurate diagnosis prevents misdiagnosis, such as with pyoderma gangrenosum.
This review aids clinicians in utilizing laboratory diagnostics for thrombotic and vasculopathic diseases.