Related Experiment Video
Updated: Nov 9, 2025

Murine Kidney Transplant Technique
Published on: October 20, 2015
[De novo thombotic microangiopathy (TMA) after incompatible AB0 renal transplantation]
Thilo Kolb1, Lars Christian Rump1
1Klinik für Nephrologie, Universitätsklinikum Düsseldorf.
History:
We report a 57-year-old patient admitted to our hospital for planned AB0-incompatible living kidney transplantation.
Findings And Diagnosis:
On day 3 post operationem, clear laboratory evidence of de novo TMA developed. Renal detoxification stagnated with initial regular course.
Therapy And Course:
By using eculizumab 900 mg on d3 and d10 post operationem, we were able to suppress TMA with a sustained success.
Conclusion:
It has to be discussed whether an early use of eculizumab in cases of suspected de novo TMA is a safe way to prevent graft dysfunction and thus to improve the poor prognosis for graft and recipient described in the literature.
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