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Transmethylation hypothesis of schizophrenia: methionine and nicotinic acid
International Pharmacopsychiatry
|January 1, 1977
Abstract:
The transmethylation hypothesis of schizophrenia was reviewed with considerations that large doses of methionine when combined with a monoamine oxidase inhibitor lead to exacerbation of psychotic symptoms in a significant percentage of chronic schizophrenic patients. It was noted that nicotinic acid in the dosage of 3,000 mg/day can neither prevent nor counteract the psychopathology thus induced.