Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Hand hygiene01:23

Hand hygiene

5.0K
Asepsis is the practice of preventing or breaking the chain of infection. The nurse employs aseptic techniques to prevent the spread of microorganisms and reduce the risk of diseases. Hand hygiene is the cornerstone of aseptic techniques and is classified into medical and surgical asepsis. Medical asepsis includes hand hygiene and the use of gloves. Surgical asepsis, or the sterile technique, refers to practices that render and keep objects and areas free of microorganisms.
Hand washing...
5.0K
Pulmonary Tuberculosis IV01:26

Pulmonary Tuberculosis IV

258
Tuberculosis, more commonly referred to as TB, is an infectious disease stemming from Mycobacterium tuberculosis. While it primarily impacts the lungs, TB can also affect other body areas. Given its severity and global impact, timely and accurate diagnosis is crucial for controlling its spread and improving patient outcomes.
Several diagnostic approaches are used to detect TB. The conventional method is the Tuberculin Skin Test (TST), also known as the Mantoux test. However, this method has...
258
Antihypertensive Drugs: Thiazide-Class Diuretics01:15

Antihypertensive Drugs: Thiazide-Class Diuretics

1.2K
Thiazide diuretics are sulfonamide derivatives featuring a benzothiadiazine ring system in their molecular structure. Based on this structure, thiazide diuretics can be categorized into two groups: thiazide-type and thiazide-like diuretics. Thiazide-type diuretics, including hydrochlorothiazide and chlorothiazide, consist of a benzothiadiazine backbone with an attached sulfonamide group. Thiazide-like diuretics, such as chlorthalidone and indapamide, lack the thiazide ring but demonstrate...
1.2K
Phase I Reactions: Oxidation of Aliphatic and Aromatic Carbon-Containing Systems01:19

Phase I Reactions: Oxidation of Aliphatic and Aromatic Carbon-Containing Systems

464
Phase I biotransformation reactions are integral to drug metabolism, predominantly involving oxidative, reductive, and hydrolytic transformations. Chief among these are oxidative reactions, which enhance the hydrophilicity of xenobiotics and introduce polar functional groups to facilitate their elimination from the body.
Oxidation reactions are fundamental in aromatic carbon-containing systems. An example is the hydroxylation of phenobarbital, a process that transforms it into...
464
Antihypertensive Drugs: Potassium-Sparing Diuretics01:28

Antihypertensive Drugs: Potassium-Sparing Diuretics

1.8K
Liddle syndrome is a genetically inherited form of hypertension characterized by the overactivity of epithelial sodium channels in the nephron, the functional unit of the kidney. This heightened activity leads to increased sodium reabsorption and excessive excretion of potassium. To counteract this, potassium-sparing diuretics such as amiloride are used. They function by blocking these sodium channels, thereby reducing the influx of sodium into the epithelial cells and minimizing the loss of...
1.8K
Antiepileptic Drugs: Potassium Channel Activators01:20

Antiepileptic Drugs: Potassium Channel Activators

406
Ezocgabine or retigabine, an antiepileptic drug of remarkable efficacy, has revolutionized the management of seizures. It is a potassium channel activator, explicitly targeting the family of Q subtype potassium channels. It enhances the transmembrane potassium currents, regulating neuronal excitability. This action stabilizes the resting membrane potential, a pivotal factor in mitigating the hyperexcitability that characterizes epilepsy.
Ezogabine has gained approval as an adjunctive treatment...
406

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Development and Validation of a Comprehensive Acute Encephalitis Syndrome Severity Score in Children with Acute Encephalitis Syndrome.

Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine·2026
Same author

Pupillary Hippus: A Rare Manifestation of Nonconvulsive Status Epilepticus in a Child with Ivermectin Poisoning.

Annals of Indian Academy of Neurology·2026
Same author

Acute Necrotising Pancreatitis: A Dreadful Complication Secondary to Valproate Usage in a Female Child with Neurocysticercosis.

Annals of Indian Academy of Neurology·2026
Same author

Acquired Motor-Sensory Polyneuropathy as a Rare Manifestation of Seronegative Celiac Disease in an Adolescent Boy.

Annals of Indian Academy of Neurology·2026
Same author

Dengue-triggered opsoclonus myoclonus ataxia syndrome in an infant.

Tropical doctor·2026
Same author

Author Response: A Neurological Outcome Score for Ventilated PICU Patients Should Only Include Neurological, Objective Outcome Parameters.

Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine·2025
Same journal

Evaluation of sepsis screening and matrix-assisted laser desorption ionisation-time of flight mass spectrometry for the diagnosis of neonatal candidaemia in a Sub-Himalayan tertiary centre in India.

Tropical doctor·2026
Same journal

A rapid turn for the worse: Steroid-responsive pulmonary haemorrhage in leptospirosis.

Tropical doctor·2026
Same journal

An unusual presentation of scrub typhus as tetany: A case report.

Tropical doctor·2026
Same journal

Campylobacter beyond the gut: A case series of <i>Campylobacter jejuni</i> bacteraemia with atypical presentations.

Tropical doctor·2026
Same journal

External ophthalmomyiasis presenting with pseudomembranous conjunctivitis and periorbital oedema: Three cases caused by <i>Oestrus ovis</i>.

Tropical doctor·2026
Same journal

Suspected iatrogenic oesophageal perforation presenting as right-sided pneumothorax in a preterm neonate: Diagnostic challenges and management.

Tropical doctor·2026
See all related articles

Related Experiment Video

Updated: Nov 9, 2025

The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis
11:39

The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis

Published on: July 11, 2013

39.2K

Isoniazid induced palmoplantar hyperhidrosis.

Prateek K Panda1,2,3, Sonalika Mehta1,2,3, Indar K Sharawat1,2,3

  • 1Assitant professor, Pediatric Neurology Division, Department of Pediatrics, All India Institute of Medical Sciences, Rishikesh, India.

Tropical Doctor
|April 15, 2021
PubMed
Summary
This summary is machine-generated.

Isoniazid-induced secondary focal hyperhidrosis, a rare side effect, can manifest as excessive palm and sole sweating. Pyridoxine supplementation effectively reversed these symptoms in a teenage patient, suggesting a potential treatment.

Keywords:
Autonomic neuropathyantitubercular drugssensory neuropathysweating

More Related Videos

Chronic Post-Ischemia Pain Model for Complex Regional Pain Syndrome Type-I in Rats
07:12

Chronic Post-Ischemia Pain Model for Complex Regional Pain Syndrome Type-I in Rats

Published on: January 21, 2020

8.0K
Quantitative Autonomic Testing
11:40

Quantitative Autonomic Testing

Published on: July 19, 2011

57.9K

Related Experiment Videos

Last Updated: Nov 9, 2025

The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis
11:39

The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis

Published on: July 11, 2013

39.2K
Chronic Post-Ischemia Pain Model for Complex Regional Pain Syndrome Type-I in Rats
07:12

Chronic Post-Ischemia Pain Model for Complex Regional Pain Syndrome Type-I in Rats

Published on: January 21, 2020

8.0K
Quantitative Autonomic Testing
11:40

Quantitative Autonomic Testing

Published on: July 19, 2011

57.9K

Area of Science:

  • Neurology
  • Dermatology
  • Pharmacology

Background:

  • Secondary focal hyperhidrosis involves complex autonomic nervous system dysfunction.
  • Palmoplantar hyperhidrosis is linked to polyneuropathies, but not previously with isoniazid.

Observation:

  • A 15-year-old boy undergoing neurotuberculosis treatment developed burning sensations and hyperhidrosis of palms and soles.
  • Symptoms appeared five months after initiating antitubercular therapy, including isoniazid.

Findings:

  • Oral pyridoxine supplementation led to significant reduction in paresthesia and hyperhidrosis within four months.
  • This suggests a direct link between isoniazid therapy and the observed secondary focal hyperhidrosis.

Implications:

  • Pyridoxine supplementation is a potential first-line treatment for isoniazid-induced secondary focal hyperhidrosis.
  • This approach may prevent the need for more invasive treatments like antiperspirants.