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Novel mouse model expands potential human α-cell research

Theodore Dos Santos1,2, Patrick E MacDonald1,2

  • 1Department of Pharmacology, University of Alberta, Edmonton, Alberta, Canada.

Islets
|April 15, 2021
PubMed

Abstract:

A glucagon knock-out mouse with preserved GLP-1 and GLP-2 secretion allows for the improved study of transplanted human islets and glucagon responses- providing an unprecedented resource in human α-cell and diabetes research.

Keywords:
Animal modelGene editingGlucagonIsletsTransplantationα-cells

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