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Combination Therapies and Personalized Medicine

Combination Therapies and Personalized Medicine

Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...

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Predictive Immune Modeling of Solid Tumors

Predictive Immune Modeling of Solid Tumors

Published on: February 25, 2020

Comprehensive tumor molecular profile analysis in clinical practice.

Mustafa Özdoğan¹, Eirini Papadopoulou², Nikolaos Tsoulos³

¹Division of Medical Oncology, Memorial Hospital, Antalya, Turkey.

BMC Medical Genomics

|April 15, 2021

Summary

Next Generation Sequencing (NGS) tumor profiling identifies actionable alterations in most cancer patients, guiding targeted and immunotherapy decisions. Simultaneous biomarker analysis significantly increases treatment options, with about half of patients potentially eligible for immunotherapy.

Keywords:

Immunotherapy Microsatellite instability Molecular profile Next Generation Sequencing PD-L1 Targeted treatment Tumor mutation burden

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Glycomics-Guided Glycoproteomics Facilitates Comprehensive Profiling of the Glycoproteome in Complex Tumor Microenvironments

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Published on: February 7, 2025

Area of Science:

Oncology
Genomics
Precision Medicine

Background:

Next Generation Sequencing (NGS) is crucial for identifying predictive biomarkers for targeted cancer therapies.
Immunotherapies are advancing cancer treatment, with Programmed Death-ligand 1 (PD-L1), Microsatellite instability (MSI), and Tumor Mutational Burden (TMB) as key biomarkers.

Purpose of the Study:

To evaluate the clinical utility of comprehensive tumor molecular profiling using a 161-gene NGS panel.
To assess the combined value of targeted therapy and immunotherapy biomarkers in guiding cancer treatment decisions.

Main Methods:

Analyzed tumor molecular profiles of 610 cancer patients using a 161-gene NGS panel.
Investigated immunotherapy biomarkers (TMB, MSI, PD-L1) alongside targeted therapy markers.

Main Results:

Actionable alterations were detected in 77.87% of patients.
Information for on-label/off-label treatment was provided to 54.75% of patients.
Including immunotherapy biomarkers increased on-label treatment recommendations by 22.92%.

Conclusions:

NGS tumor profiling is a primary method for cancer treatment decision-making.
Simultaneous analysis of targeted and immunotherapy biomarkers enhances tumor characterization and actionable insights.
Approximately 50% of patients may be eligible for on-label immune checkpoint inhibitor (ICI) treatment based on biomarker analysis.