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Interplay Between CMGC Kinases Targeting SR Proteins and Viral Replication: Splicing and Beyond
Florentin Pastor1, Lulzim Shkreta2, Benoit Chabot2
1International Center for Infectiology Research (CIRI), INSERM U1111, CNRS UMR5308, Université de Lyon (UCBL1), Lyon, France.
Frontiers in Microbiology
|April 15, 2021
Summary
CMGC kinases phosphorylate serine/arginine-rich (SR) proteins, impacting gene expression and viral replication. This review explores their roles in viral infections for potential therapeutic strategies.
Area of Science:
- Molecular Biology
- Virology
- Biochemistry
Background:
- Protein phosphorylation is a key post-translational modification regulating protein function.
- Serine/arginine-rich (SR) proteins are crucial for gene expression via splicing.
- CMGC kinases target SR proteins, influencing cellular processes and viral replication.
Purpose of the Study:
- To review the known and emerging roles of CMGC kinases in phosphorylating SR proteins.
- To elucidate the interplay between CMGC kinases and various viral families.
- To understand the pro- or anti-viral phenotypes of CMGC kinases for translational applications.
Main Methods:
- Literature review of studies on CMGC kinases, SR proteins, and viral replication.
- Analysis of kinase activity and phosphorylation targets.
- Examination of viral replication mechanisms influenced by CMGC kinases.
Main Results:
- CMGC kinases (CDKs, MAPKs, GSKs, CLKs) regulate gene expression through SR protein phosphorylation.
- These kinases influence viral replication through direct or indirect interactions.
- Evidence suggests both pro- and anti-viral roles for CMGC kinases.
Conclusions:
- CMGC kinases are critical regulators of SR protein phosphorylation and gene expression.
- Their involvement in viral replication presents potential therapeutic targets.
- Further research is needed to fully assess their translational opportunities in antiviral therapies.
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