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Updated: Nov 9, 2025

Assessing Cellular Target Engagement by SHP2 PTPN11 Phosphatase Inhibitors
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Assessing Cellular Target Engagement by SHP2 PTPN11 Phosphatase Inhibitors

Published on: July 17, 2020

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Protein kinase PIM2: A simple PIM family kinase with complex functions in cancer metabolism and therapeutics

Yixin Wang1, Jing Xiu1, Chune Ren1

  • 1Department of Reproductive Medicine, Affiliated Hospital of Weifang Medical University, Weifang, Shandong Province, P.R. China.

Journal of Cancer
|April 15, 2021
PubMed

Insights

Proviral integration site for Moloney murine leukemia virus 2 (PIM2) kinase is an oncogene driving cancer cell survival and proliferation. Targeting PIM2 kinase offers a promising therapeutic strategy for various human cancers.

Area of Science:

  • Oncology
  • Molecular Biology
  • Biochemistry

Background:

  • Proviral integration site for Moloney murine leukemia virus 2 (PIM2) kinase is implicated as an oncogene in diverse cancers, including leukemia and solid tumors.
  • PIM2 kinase promotes cancer progression by activating genes essential for cell survival, proliferation, and cell-cycle progression.

Purpose of the Study:

  • To review PIM2 kinase signaling pathways and its role in neoplastic diseases.
  • To discuss the development and future perspectives of PIM2 kinase inhibitors for cancer therapy.

Main Methods:

  • Literature review of PIM2 kinase signaling pathways.
  • Analysis of PIM2 mechanisms in various cancers.
  • Summary of PIM2 inhibitor development and therapeutic potential.

Main Results:

  • PIM2 kinase is a key regulator of tumorigenesis, with numerous substrates identified.
  • Several PIM2 kinase inhibitors (e.g., SMI-4a, SGI-1776) have been developed.
  • PIM2 plays a significant role in both leukemia and solid tumor development.

Conclusions:

  • PIM2 kinase is a critical therapeutic target for human cancers.
  • Further development of PIM2 inhibitors holds significant promise for future cancer treatment strategies.
Keywords:
PIM2inhibitorsoncogenephosphorylationprotein kinase

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