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Related Concept Videos

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Bones are dynamic organs that require a rich supply of oxygen and nutrients. Around 5% to 10% of the cardiac output supplies blood to the bones. A typical long bone has three main sources: the nutrient artery, the metaphyseal and epiphyseal arteries, and the periosteal arteries.
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All bones comprise an outer layer of compact bone, and an interior made up of spongy bone tissue, also called cancellous or trabecular bone. In long bones, spongy bone tissue is mainly found in the interior of the epiphyses (broad ends of the bone).
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Compact Bone01:27

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Most bones contain compact and spongy osseous tissue, but their distribution and concentration vary based on the bone's overall function.
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Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
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Gross Anatomy of Bone01:17

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The two main features of a long bone are the diaphysis and the epiphysis.
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The Muscle Cuff Regenerative Peripheral Nerve Interface for the Amplification of Intact Peripheral Nerve Signals
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Crosstalk between Bone and Nerves within Bone.

Qian-Qian Wan1, Wen-Pin Qin1, Yu-Xuan Ma1

  • 1State Key Laboratory of Military Stomatology and National Clinical Research Center for Oral Diseases and Shaanxi Key Laboratory of Stomatology Department of Prosthodontics School of Stomatology The Fourth Military Medical University Xi'an Shaanxi 710032 China.

Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
|April 15, 2021
PubMed
Summary
This summary is machine-generated.

This review explores the bidirectional communication between bone and peripheral nerves. Understanding this nerve-bone crosstalk is crucial for developing new treatments for bone diseases and injuries.

Keywords:
bioactive factorsbone metabolismcrosstalknerve growthperipheral nerves

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Area of Science:

  • Bone Biology
  • Neuroscience
  • Biomedical Engineering

Background:

  • Research has extensively studied intrabony nerves' effects on bone.
  • The reciprocal influence of bone on intrabony nerves remains underexplored.
  • Peripheral nerves modulate bone through secreted factors and nerve-resident cells.

Purpose of the Study:

  • To comprehensively analyze the crosstalk between bone and intrabony peripheral nerves.
  • To highlight the role of bone in supporting and regulating intrabony nerves.
  • To discuss the implications of this crosstalk in physiological and pathological states.

Main Methods:

  • Literature review and synthesis of existing research on nerve-bone interactions.
  • Analysis of signaling pathways involving neurotransmitters, neuropeptides, and growth factors.
  • Examination of the role of bone microenvironment and bone marrow stromal cells.

Main Results:

  • Peripheral nerves influence bone development and repair via secreted signaling molecules.
  • Bone provides mechanical support and a protective niche for intrabony nerves.
  • A complex interplay of chemical, mechanical, and electrical cues regulates intrabony nerves within bone.

Conclusions:

  • The crosstalk between bone and peripheral nerves is bidirectional and significant.
  • This interaction is implicated in various bone diseases, including osteoporosis and osteoarthritis.
  • Harnessing nerve-bone crosstalk offers potential for bone tissue engineering and therapeutic interventions.