Nanostructured Dense Collagen-Polyester Composite Hydrogels as Amphiphilic Platforms for Drug Delivery
Xiaolin Wang1,2, Olivier Ronsin3,4, Basile Gravez5
1School of Pharmacy and State Key Laboratory of Quality Research in Chinese Medicine Macau University of Science and Technology Taipa Macao 999078 China.
Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
|April 15, 2021
Summary
This study introduces a novel collagen-polyester composite platform for advanced medicated biomaterials. The new fabrication method enhances physical properties and enables controlled drug delivery, showing promise for tissue engineering and drug delivery applications.
Area of Science:
- Biomaterials Science
- Polymer Chemistry
- Biomedical Engineering
Background:
- Collagen-polyester composites are promising for medicated biomaterials.
- Existing methods yield hydrogels with poor physical properties and low drug loading.
Purpose of the Study:
- To develop an improved amphiphilic composite platform using dense collagen hydrogels and biodegradable polyesters.
- To establish a novel fabrication method for enhanced biomaterial properties and drug delivery.
Main Methods:
- In situ nanoprecipitation of polyesters within a 3D collagen network.
- Fabrication of composites using poly(lactic-co-glycolic acid) (PLGA) and poly(lactic acid) (PLA).
- Evaluation of mechanical properties, hydration, drug release kinetics, and cytotoxicity.
Main Results:
- Composites with PLGA and PLA showed improved mechanical properties and high hydration compared to pure collagen hydrogels.
- Tunable release kinetics of spironolactone over one month were achieved.
- No cytotoxicity was observed on fibroblasts and keratinocytes.
Conclusions:
- The novel fabrication process enhances physical properties of collagen hydrogels and enables controlled drug delivery.
- These collagen-polyester composites offer ease of fabrication, tunable compositions, and preliminary safety, favoring clinical translation for drug delivery and tissue engineering.
