Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same authorSame journal

Multiparametric evaluation of structure-photophysical activity correlation: A case study of pyrene-tethered chalcone.

Acta chimica Slovenica·2026
Same author

Foliar Fate of Phthalate Esters in Lettuce: Uptake, Phytotoxicity, and Metabolic Responses.

Journal of agricultural and food chemistry·2026
Same author

Molecular characterization of a naturally occurring isolate of Begomovirus solanumkarnatakaense causing breakdown of Ty-3-mediated resistance in tomato plants with increased disease severity under elevated temperature.

BMC plant biology·2026
Same author

Chemico-biological evaluation of carpachromene against key antimicrobial protein targets: an integrated <i>in-silico, in-vitro</i> approach for mechanistic insights.

Frontiers in pharmacology·2026
Same author

Gamma-Aminobutyric acid profiling (GABA) and standardization of in-vitro regeneration protocol in tomato (Solanum lycopersicum L.) genotypes.

Journal, genetic engineering & biotechnology·2026
Same author

Relay-Assisted Communications over Multi-Cluster Two-Wave Fading Channels.

Sensors (Basel, Switzerland)·2026

Related Experiment Video

Updated: Nov 9, 2025

Ion Mobility-Mass Spectrometry Techniques for Determining the Structure and Mechanisms of Metal Ion Recognition and Redox Activity of Metal Binding Oligopeptides
11:04

Ion Mobility-Mass Spectrometry Techniques for Determining the Structure and Mechanisms of Metal Ion Recognition and Redox Activity of Metal Binding Oligopeptides

Published on: September 7, 2019

9.5K

Exploring Bikaverin as Metal Ion Biosensor: A Computational Approach.

Zakir Hussain, Haamid Rasool Bhat, Tahira Naqvi

    Acta Chimica Slovenica
    |April 15, 2021
    PubMed
    Summary

    Fungal pigment bikaverin acts as a biosensor for detecting bioavailable metal ions. Computational studies and experiments show bikaverin strongly binds and enhances fluorescence with calcium (Ca2+), magnesium (Mg2+), and aluminum (Al3+).

    More Related Videos

    Biosensor-based High Throughput Biopanning and Bioinformatics Analysis Strategy for the Global Validation of Drug-protein Interactions
    08:31

    Biosensor-based High Throughput Biopanning and Bioinformatics Analysis Strategy for the Global Validation of Drug-protein Interactions

    Published on: December 1, 2020

    5.3K
    Analysis of AtHIRD11 Intrinsic Disorder and Binding Towards Metal Ions by Capillary Gel Electrophoresis and Affinity Capillary Electrophoresis
    07:54

    Analysis of AtHIRD11 Intrinsic Disorder and Binding Towards Metal Ions by Capillary Gel Electrophoresis and Affinity Capillary Electrophoresis

    Published on: August 22, 2018

    6.2K

    Related Experiment Videos

    Last Updated: Nov 9, 2025

    Ion Mobility-Mass Spectrometry Techniques for Determining the Structure and Mechanisms of Metal Ion Recognition and Redox Activity of Metal Binding Oligopeptides
    11:04

    Ion Mobility-Mass Spectrometry Techniques for Determining the Structure and Mechanisms of Metal Ion Recognition and Redox Activity of Metal Binding Oligopeptides

    Published on: September 7, 2019

    9.5K
    Biosensor-based High Throughput Biopanning and Bioinformatics Analysis Strategy for the Global Validation of Drug-protein Interactions
    08:31

    Biosensor-based High Throughput Biopanning and Bioinformatics Analysis Strategy for the Global Validation of Drug-protein Interactions

    Published on: December 1, 2020

    5.3K
    Analysis of AtHIRD11 Intrinsic Disorder and Binding Towards Metal Ions by Capillary Gel Electrophoresis and Affinity Capillary Electrophoresis
    07:54

    Analysis of AtHIRD11 Intrinsic Disorder and Binding Towards Metal Ions by Capillary Gel Electrophoresis and Affinity Capillary Electrophoresis

    Published on: August 22, 2018

    6.2K

    Area of Science:

    • Biochemistry
    • Computational Chemistry
    • Materials Science

    Background:

    • Fungi produce diverse pigments with potential applications.
    • Bikaverin, a fungal pigment, has unique optical properties.
    • Biosensors are crucial for detecting metal ions in various environments.

    Purpose of the Study:

    • To computationally investigate bikaverin as a biosensor for bioavailable metal ions.
    • To explore the binding interactions and optical property changes of bikaverin upon metal ion complexation.
    • To determine the selectivity and sensitivity of bikaverin for specific metal ions.

    Main Methods:

    • Computational modeling to optimize ground and excited state geometries of bikaverin and its metal ion adducts.
    • Systematic screening of thirteen bioavailable metal ions for binding affinity.
    • Analysis of optical properties, specifically fluorescence intensity changes upon binding.
    • Experimental validation using preliminary fluorescence studies.

    Main Results:

    • Bikaverin exhibits varying binding strengths with thirteen screened metal ions.
    • Calcium (Ca2+), magnesium (Mg2+), and aluminum (Al3+) were identified as the strongest binders.
    • Fluorescence intensity enhancement was observed in the order Ca2+ > Al3+ > Mg2+ upon binding.
    • Computational predictions of selectivity towards Ca2+ were experimentally confirmed.

    Conclusions:

    • Bikaverin demonstrates potential as a selective fluorescent biosensor for bioavailable metal ions, particularly Ca2+.
    • The study provides insights into the computational design of pigment-based metal ion sensors.
    • Bikaverin's fluorescence enhancement in the presence of Ca2+ in aqueous media validates its utility.