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Associations Between Cholecalciferol Supplementation and Self-Reported Symptoms Among Women With Metastatic Breast
Patricia Maureen Sheean1, Patricia Robinson1, Mary Beth Bartolotta1
1Loyola University Chicago.
Objectives:
To assess the potential effect of cholecalciferol supplementation to reduce symptom burden for women with metastatic breast cancer (MBC).
Sample & Setting:
11 clinically stable women with estrogen receptor-positive MBC were recruited from a single cancer center for this phase 1, nonrandomized study (NCT02186015).
Methods & Variables:
Women with insufficient serum 25-hydroxyvitamin D (25[OH]D) levels qualified to receive high-dose repletion therapy. Clinical and questionnaire data on common symptoms and quality of life were obtained prior to and following supplementation.
Results:
Serum 25(OH)D increased significantly pre- versus postintervention. Trends for improvements in endocrine symptoms, bone pain, and fatigue were observed following the intervention.
Implications For Nursing:
Women achieved normal serum 25(OH)D levels after eight weeks of supplementation and reported reduced symptom burden. Vitamin D may be a low-cost supportive care therapy; however, future studies should be considered.
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