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α,β-Unsaturated γ-Peptide Foldamers.

Baptiste Legrand1, Ludovic T Maillard1

  • 1Institut des Biomolécules Max Mousseron, IBMM, University of Montpellier, ENSCM, CNRS, Montpellier, France., 15 Av. Charles Flahault BP 14 491, 34093, Montpellier Cedex 5, France.

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|April 15, 2021
PubMed
Summary

Gamma-peptide foldamers, though emerging in the 1990s, are less developed than beta-peptide foldamers. This review highlights unsaturated gamma-amino acid sequences and their diverse applications.

Keywords:
antimicrobial peptidesfoldamershydrogen bondinginhibitorsvinylogous amino acidsγ-peptides

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Area of Science:

  • Organic Chemistry
  • Polymer Science
  • Biomolecular Chemistry

Background:

  • Gamma-peptide foldamers emerged in the 1990s but lag behind beta-peptide foldamers in development and application.
  • Few gamma-oligomer structures are reported, with limited exploration of their potential.

Purpose of the Study:

  • To provide a comprehensive overview of gamma-peptide foldamers containing alpha,beta-unsaturated gamma-amino acids.
  • To explore the conformational diversity driven by Z/E isomerism in these foldamers.
  • To showcase applications in health, catalysis, and materials science.

Main Methods:

  • Literature review of gamma-peptide foldamers containing alpha,beta-unsaturated gamma-amino acids.
  • Analysis of structure-property relationships based on Z/E double bond configurations.
  • Compilation of reported applications in various scientific fields.

Main Results:

  • Unsaturated gamma-amino acids introduce planar restrictions, leading to diverse conformations (helical to extended).
  • Z/E configurations of the double bond significantly influence foldamer structure and behavior.
  • Reported applications span medicinal chemistry, catalysis, and materials science.

Conclusions:

  • Gamma-peptide foldamers with unsaturated amino acids offer tunable structural properties.
  • These foldamers present promising avenues for innovation in health, catalysis, and materials.
  • Further research into gamma-peptide foldamers is warranted due to their versatile applications.