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Endoscopic changes in patients diagnosed with acute pancreatitis
Łukasz Nawacki1, Magdalena Kołomańska2, Piotr Bryk2
1Collegium Medicum, The Jan Kochanowski University of Kielce, Kielce, Poland - lukasznawacki@gmail.com.
Minerva Gastroenterology
|April 15, 2021
Summary
Proton pump inhibitors may be crucial for acute pancreatitis patients, as endoscopy revealed upper gastrointestinal lesions in 94% of those hospitalized. Standard NSAID treatment can also cause mucosal defects, suggesting routine PPI use is warranted.
Area of Science:
- Gastroenterology
- Internal Medicine
Background:
- Debate exists regarding the routine use of proton pump inhibitors (PPIs) in acute pancreatitis (AP) management.
- Assessing upper gastrointestinal (GI) endoscopic lesions in AP patients is crucial.
Purpose of the Study:
- To evaluate the prevalence and nature of upper GI endoscopic lesions in patients hospitalized for acute pancreatitis.
Main Methods:
- Prospective analysis of patients hospitalized for AP undergoing upper GI endoscopy within 48 hours.
- Statistical analysis including descriptive statistics, Shapiro-Wilk Test, logistic regression, ANOVA, and t-tests.
Main Results:
- Endoscopic examination was performed on 85 of 476 hospitalized AP patients.
- Upper GI lesions were observed in 94.12% (80 patients) of the examined group.
- Lesion prevalence varied across pancreatitis severity: 52.94% mild, 32.94% moderate, 14.12% severe.
Conclusions:
- A high incidence of upper GI lesions is present in hospitalized AP patients.
- Non-steroidal anti-inflammatory drugs (NSAIDs), a standard AP treatment, can cause mucosal defects.
- Routine PPI use in AP patients is indicated due to high lesion rates and NSAID-induced damage.
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