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Protein-Based Hybrid Responsive Microparticles for Wound Healing
Hui Zhang1,2, Zhuohao Zhang2, Han Zhang2
1Department of Clinical Laboratory, Institute of Translational Medicine, The Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing 210002, China.
ACS Applied Materials & Interfaces
|April 15, 2021
Summary
New natural polymer microparticles with black phosphorus quantum dots (BPQDs) enable controlled drug release for wound healing. Near-infrared light triggers drug release, promoting tissue repair and providing antibacterial effects.
Area of Science:
- Biomaterials Science
- Polymer Chemistry
- Nanotechnology
Background:
- Natural polymer materials are crucial for advanced wound treatment.
- Developing smart drug delivery systems enhances therapeutic efficacy.
Purpose of the Study:
- To create novel, controllable, responsive microparticles for enhanced drug delivery and wound healing.
- To investigate the near-infrared (NIR) responsive drug release mechanism.
Main Methods:
- Hybrid microparticles synthesized using silk fibroin, gelatin, agarose, and black phosphorus quantum dots (BPQDs).
- Growth factors and antibacterial peptides encapsulated within the microparticles.
- NIR irradiation used to trigger drug release via gelatin melting and phase transformation.
Main Results:
- BPQD-laden microparticles demonstrated controlled release of encapsulated drugs under NIR irradiation.
- In vitro and in vivo studies confirmed growth factor release promoted neovascularization.
- Microparticles exhibited antibacterial properties due to encapsulated antibacterial peptides.
Conclusions:
- The developed BPQD-loaded natural protein hybrid microparticles offer a promising platform for controlled drug delivery.
- NIR-responsive microparticles facilitate effective wound healing by promoting tissue regeneration and preventing infection.
