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Related Experiment Video

Updated: Nov 9, 2025

Use of MRI-ultrasound Fusion to Achieve Targeted Prostate Biopsy
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Published on: April 9, 2019

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Prostate cancer detection by targeted prostate biopsy using the 3D Navigo system: a prospective study.

Alexandre Magnier1, Cosmina Nedelcu2, Samuel Chelly3

  • 1Urology Department, University Hospital of Angers, 4 rue Larrey, 49933, Angers Cedex 9, France. alexandre.magnier@chu-angers.fr.

Abdominal Radiology (New York)
|April 15, 2021
PubMed
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The 3D Navigo™ system enables feasible and safe prostate targeted biopsies (TB), detecting clinically significant prostate cancer (CSC) effectively. This MRI-TRUS fusion technology shows a strong correlation with radical prostatectomy results for cancer staging.

Area of Science:

  • Urology
  • Medical Imaging
  • Oncology

Background:

  • Prostate cancer diagnosis relies on accurate detection of clinically significant disease.
  • Magnetic Resonance Imaging (MRI) and Transrectal Ultrasound (TRUS) fusion technologies aim to improve biopsy accuracy.
  • The 3D Navigo™ system integrates MRI and TRUS for targeted biopsies (TB).

Purpose of the Study:

  • To evaluate the detection rate of clinically significant prostate cancer (CSC) using the 3D Navigo™ system for targeted biopsies (TB).
  • To assess the feasibility and safety of the 3D Navigo™ system in prostate cancer diagnostics.

Main Methods:

  • Prospective study of 304 patients undergoing TB with the 3D Navigo™ system (June 2014-May 2018).
  • Pre-biopsy 3-Tesla MRI with Prostate Imaging Reporting and Data System version 2 (PIRADS) scoring.
Keywords:
Clinically significant prostate cancerFusion biopsyPIRADS version 2 scoreProstate cancerTargeted biopsies

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  • Clinically significant prostate cancer (CSC) defined as ISUP score ≥ 2.

    • Main Results:

    • Prostate cancer (PCa) and CSC detected in 70.4% and 47.7% of patients, respectively.
    • PIRADS score ≥ 4 was a significant risk factor for CSC (OR 5.0) and PIRADS 5 (OR 3.2).
    • High correlation (r=0.60) between TB and radical prostatectomy (RP) specimens for PCa detection; no significant difference in pathological outcomes.

    Conclusions:

    • MRI-TRUS fusion targeted biopsies (TB) using the 3D Navigo™ system are feasible and safe for detecting CSC.
    • The system demonstrates a positive correlation with radical prostatectomy (RP) findings for ISUP scores, enhancing diagnostic reliability.