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Does Localization Technique Matter for Non-palpable Breast Cancers?

Anees B Chagpar1, Carlos Garcia-Cantu2, Marissa M Howard-McNatt3

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The American Surgeon
|April 15, 2021
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Summary
This summary is machine-generated.

Choosing a breast tumor localization technique does not impact surgical margins or tissue removed. This study compared wire localization, radioactive seed, and Savi Scout, finding no significant differences in outcomes for breast cancer surgery.

Keywords:
breastsurgical oncology

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Area of Science:

  • Oncology
  • Surgical Oncology
  • Radiology

Background:

  • Accurate localization of non-palpable breast tumors is crucial for breast-conserving surgery.
  • Existing localization techniques lack comparative data on margin positivity and tissue resection volume.

Purpose of the Study:

  • To compare the efficacy of different non-palpable breast tumor localization techniques.
  • To evaluate the impact of localization method on margin positivity and volume of tissue resected.

Main Methods:

  • Analysis of data from 2 randomized controlled trials (2011-2013, 2016-2018) involving 631 patients with stage 0-3 breast cancer.
  • Focus on 522 patients with non-palpable tumors requiring localization prior to breast-conserving surgery.
  • Comparison of margin positivity and tissue resection volume across wire localization (WL), radioactive seed (RS), and Savi Scout (SS) techniques.

Main Results:

  • Wire localization (89.1%) was the predominant technique, followed by radioactive seed (9.6%) and Savi Scout (1.3%).
  • No significant differences were observed in margin positivity (P=.339) or re-excision rates (P=.961) among the localization groups.
  • The volume of tissue resected also did not differ significantly between the WL, RS, and SS groups (P=.340).
  • Multivariate analysis indicated tumor size, not localization technique, significantly affected margin status (P<.001).

Conclusions:

  • The choice of localization technique for non-palpable breast tumors does not appear to influence the volume of tissue resected.
  • Surgical margin status is not significantly affected by the localization method used.
  • Tumor size is a more critical factor in determining margin status than the localization technique.