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Updated: Nov 9, 2025

Operating and Biocontainment Procedures of a Facility for Laboratory Mice with a Natural Microbiome: Immunophenotyping Procedure

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Published on: December 13, 2024

Defined mouse microbiota: An "evolving" tool.

Giuliano Bayer¹, Dana J Philpott¹

¹Department of Immunology, University of Toronto, Toronto, ON M5S 1A8, Canada.

Cell Host & Microbe

|April 15, 2021

Summary

This summary is machine-generated.

This study tracked bacterial evolution in mouse guts over time. Researchers found evidence of ongoing positive selection within the gut microbiota, impacting gnotobiotic mouse model development.

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Microbiota Analysis Using Two-step PCR and Next-generation 16S rRNA Gene Sequencing

Microbiota Analysis Using Two-step PCR and Next-generation 16S rRNA Gene Sequencing

Published on: October 15, 2019

Area of Science:

Microbiology
Evolutionary Biology
Gastroenterology

Background:

The gut microbiota plays a crucial role in host health and disease.
Understanding microbial evolution in vivo is essential for developing accurate research models.

Purpose of the Study:

To investigate the long-term evolutionary dynamics of the gut microbiota in a living organism.
To identify selective pressures acting on bacterial communities within the murine gut.

Main Methods:

Conducted one of the longest in vivo microbiota evolution studies reported to date.
Utilized murine (mouse) models to observe gut microbial community changes over an extended period.

Main Results:

Demonstrated ongoing positive selection acting on a bacterial consortium within the murine gut.
Provided empirical evidence for adaptive evolution within a complex microbial ecosystem.

Conclusions:

The gut microbiota is subject to continuous evolutionary processes driven by positive selection.
Findings have significant implications for the design and application of gnotobiotic mouse models in research.