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Updated: Nov 9, 2025

Development of Inhibitors of Protein-protein Interactions through REPLACE: Application to the Design and Development Non-ATP Competitive CDK Inhibitors
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Discovery of a novel covalent CDK4/6 inhibitor based on palbociclib scaffold

Huifang Shan1, Xinyu Ma1, Guoyi Yan2

  • 1State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu 610041, China.

European Journal of Medicinal Chemistry
|April 15, 2021
PubMed

Keywords:
CDK4CDK6Cell cycleCovalent inhibitorPalbociclib

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