Related Experiment Video
Updated: Nov 9, 2025
05:39
Dermoscopy Aids in the Diagnosis of Discoid Lupus Erythematosus
Published on: May 16, 2025
328
Rosai-Dorfman-Destombes (RDD) disease presenting as palindromic rheumatism
Amin Haghighat Jahromi1, Aaron M Goodman2, Carl K Hoh3
1Department of Radiology, University of California, UCSD Medical Center, 200 W Arbor Drive, San Diego, CA, 92103-2686, USA. ajahromi@ucsd.edu.
BMC Medical Imaging
|April 16, 2021
Summary
Rosai-Dorfman-Destombes (RDD) disease, a rare histiocytic disorder, can present unusually. This case highlights RDD manifesting as palindromic rheumatism in a young woman with sinus symptoms.
Area of Science:
- Histiocytic Disorders
- Immunology
- Rheumatology
Background:
- Rosai-Dorfman-Destombes (RDD) disease is a rare, non-Langerhans cell histiocyte proliferative and inflammatory disorder.
- Disseminated RDD is uncommon but can present with diverse symptoms.
Observation:
- A 35-year-old woman presented with joint pain, nasal congestion, and sinus lesions.
- Imaging revealed intense 18F-FDG uptake in paranasal sinuses, pelvic lymph nodes, and lower extremity osseous lesions.
- Rheumatologic work-up indicated palindromic rheumatism.
Findings:
- Histopathology confirmed Rosai-Dorfman-Destombes (RDD) disease.
- The patient was diagnosed with immune-related disseminated RDD presenting as palindromic rheumatism.
- This represents the first reported case of RDD presenting with palindromic rheumatism.
Implications:
- RDD should be considered in young patients with sinus symptoms and lymphadenopathy.
- The potential for disseminated and immune-related presentations of RDD is highlighted.
- This case broadens the clinical spectrum of Rosai-Dorfman-Destombes (RDD) disease.
Related Concept Videos
01:23Rheumatic Heart Disease I: Introduction
154
Rheumatic heart disease or RHD is a chronic condition that results from rheumatic fever, causing permanent damage to the heart valves.Etiology and Risk FactorsIt primarily arises from rheumatic fever, an inflammatory disease that can develop after untreated or inadequately treated group A streptococcal (GAS) pharyngitis. Streptococcus spreads through direct contact with oral or respiratory secretions. While the bacteria are the causative agents, factors like malnutrition, overcrowding, poor...
154
01:22Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies
194
The key clinical manifestations of Rheumatic heart disease (RHD) include several distinct cardiac symptoms.Carditis, a hallmark of acute rheumatic fever, involves inflammation of the heart's endocardium, myocardium, and pericardium. Chronic RHD often results from recurrent episodes of carditis. Its symptoms include the following:Murmurs are caused by valvular damage, especially to the mitral and aortic valves. Mitral stenosis or regurgitation is common, with characteristic heart murmurs...
194
01:25Endocarditis II: Clinical Features of Infective Endocarditis
93
Endocarditis can present various clinical features depending on the causative organism and the patient's underlying health conditions. Initially, the clinical features of infective endocarditis develop gradually, presenting with nonspecific symptoms that can be easily mistaken for other illnesses.General SymptomsEarly symptoms of infective endocarditis are fever, chills, weakness, malaise, fatigue, and weight loss. These symptoms reflect the systemic nature of the infection and the body's...
93
01:03Rous Sarcoma Virus (RSV) and Cancer
5.7K
Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand RNA genome. Its genome consists of four main open...
RSV is a retrovirus that contains two copies of a plus-strand RNA genome. Its genome consists of four main open...
5.7K
01:30Inflammatory Bowel Disease II: Crohn's Disease
546
Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
546
01:29Autoimmune Disorders
1.0K
Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
Concept and Mechanism of Autoimmune Diseases
The immune...
Concept and Mechanism of Autoimmune Diseases
The immune...
1.0K