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Targeting the stress support network regulated by autophagy and senescence for cancer treatment

Jaejin Kim1, Yeonghyeon Lee1, Kyeonghwan Roh1

  • 1School of Biological Sciences, Seoul National University, Seoul, South Korea.

Advances in Cancer Research
|April 16, 2021
PubMed

Insights

Autophagy and cellular senescence are complex tumor suppressors that can also promote cancer. Understanding their dual roles in cancer cell stress networks is key for developing effective cancer therapies.

Area of Science:

  • Oncology
  • Cellular Biology

Background:

  • Autophagy and cellular senescence are known tumor suppressive mechanisms activated by cellular stress.
  • Emerging evidence suggests these processes also exhibit pro-tumorigenic activities, highlighting the complexity of tumorigenesis.

Purpose of the Study:

  • To review the dual roles of autophagy and cellular senescence in tumorigenesis.
  • To focus on how these processes modulate stress support networks in cancer cells.

Main Methods:

  • Literature review of studies on autophagy, cellular senescence, and cancer.
  • Analysis of the interplay between these cellular processes and tumor support pathways.

Main Results:

  • Autophagy and senescence display context-dependent roles in cancer, acting as both tumor suppressors and promoters.
  • These processes significantly influence cancer cell stress response and survival pathways.

Conclusions:

  • A deeper understanding of the dual roles of autophagy and senescence is crucial for improving cancer therapy efficacy.
  • Targeting these pathways effectively could enhance cancer treatments while minimizing side effects, accelerating drug development.
Keywords:
AutophagyCellular senescenceSASPSelective autophagySenolyticsSenostaticsStress support pathwayTumorigenesis

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