Related Experiment Video
Updated: Nov 9, 2025
11:14
Detection of Low Copy Number Integrated Viral DNA Formed by In Vitro Hepatitis B Infection
Published on: November 7, 2018
18.6K
Coding-Complete Genome Sequence of Murine Hepatitis Virus Strain 3 from Brazil
Amanda Barbosa Garcia1, Ana Paula de Moraes1, Daniele Masselli Rodrigues2
1Laboratory of Virology, University of Campinas (UNICAMP), Campinas, São Paulo, Brazil.
Microbiology Resource Announcements
|April 16, 2021
Summary
Murine hepatitis virus (MHV) strain 3 is crucial for studying coronavirus. A new MHV-3 isolate sequence expands research options for understanding viral hepatitis and pathogenesis.
Area of Science:
- Virology
- Pathogenesis
- Molecular Biology
Background:
- Murine hepatitis virus (MHV) strain 3 is a key inducer of viral hepatitis.
- Understanding coronavirus biology and pathogenesis relies heavily on MHV-3 research.
- Currently, only one MHV-3 sequence is publicly available.
Purpose of the Study:
- To sequence a new, representative isolate of Murine hepatitis virus (MHV) strain 3.
- To expand the available genetic resources for MHV-3 research.
- To facilitate further studies into coronavirus biology and pathogenesis.
Main Methods:
- Whole-genome sequencing of a novel MHV-3 isolate.
- Bioinformatic analysis of the obtained viral genome sequence.
Main Results:
- A new, complete genome sequence for an MHV-3 isolate has been generated.
- This sequence represents a distinct variant within the MHV-3 group.
- The addition of this sequence enriches the available genetic data for MHV-3.
Conclusions:
- The newly sequenced MHV-3 isolate provides a valuable new resource for researchers.
- This expands the toolkit for investigating MHV-3-associated viral hepatitis.
- Further studies can now utilize this additional genetic data to explore coronavirus diversity and disease mechanisms.
