Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

What is Gene Expression?

What is Gene Expression?

A gene is a stretch of DNA that serves as the blueprint for functional RNAs and proteins. Since DNA is comprised of nucleotides and proteins are comprised of amino acids, a mediator is required to convert the information encoded in DNA into proteins. This mediator is the messenger RNA (mRNA). mRNA copies the blueprint from DNA by a process called transcription. In eukaryotes, transcription occurs in the nucleus by complementary base-pairing with the DNA template. The mRNA is then...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Proteostasis is disrupted in human endothelial cells by serum from ATTR patients and is rescued by tafamidis treatment.

Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis·2026

Same author

Gene expression integration and similarity score-based modeling improve risk stratification in idiopathic venous thrombophilia.

Journal of thrombosis and haemostasis : JTH·2026

Same author

De novo nitric oxide synthesis drives tactile hypersensitivity induced by ATP-sensitive potassium channel opening in mice: relevance to migraine and other headache disorders.

Pain·2026

Same author

On a quest for fingerprints of crystalglobulinemia on platelets and endothelium.

Blood vessels, thrombosis & hemostasis·2026

Same author

TRPV1 Downregulation Impairs Prostate Cancer Growth: Functional and Translational Insights from Cellular and <i>In Vivo</i> Models.

International journal of biological sciences·2026

Same author

Dim Flicker: An Endogenous Visual Percept and Its Disease Associations.

Journal of clinical medicine·2026

Same journal

MT-MRI for detection of renal interstitial fibrosis in renovascular disease.

Scientific reports·2026

Same journal

Detection of underground objects from GPR data using a lightweight YOLO-based approach.

Scientific reports·2026

Same journal

Early systemic inflammatory-metabolic trajectory phenotypes are associated with survival outcomes in metastatic renal cell carcinoma treated with nivolumab.

Scientific reports·2026

Same journal

Water balance components in a dry-seeded rice-wheat system: Untangling the effects of tillage and mulching practices.

Scientific reports·2026

Same journal

Topological approaches to quantum tensor train compression via ZX-calculus and SVD.

Scientific reports·2026

Same journal

determinants of flood impacts and adaptive capacity among market vendors in Walukuba-Masese, Jinja city, Uganda.

Scientific reports·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Nov 9, 2025

Modeling Neural Immune Signaling of Episodic and Chronic Migraine Using Spreading Depression In Vitro

Modeling Neural Immune Signaling of Episodic and Chronic Migraine Using Spreading Depression In Vitro

Published on: June 13, 2011

Changes in the gene expression profile during spontaneous migraine attacks.

Lisette J A Kogelman¹, Katrine Falkenberg², Alfonso Buil³

¹Danish Headache Center, Department of Neurology, Rigshospitalet Glostrup, Glostrup, Denmark. Lisette.kogelman@regionh.dk.

Scientific Reports

|April 16, 2021

Summary

This summary is machine-generated.

Migraine attacks show specific gene expression changes, particularly in fatty acid oxidation and immune pathways. These findings offer new insights into migraine pathophysiology and treatment effectiveness.

More Related Videos

3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache

3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache

Published on: June 2, 2014

Determining Genetic Expression Profiles in C. elegans Using Microarray and Real-time PCR

Determining Genetic Expression Profiles in C. elegans Using Microarray and Real-time PCR

Published on: July 30, 2011

Related Experiment Videos

Last Updated: Nov 9, 2025

Modeling Neural Immune Signaling of Episodic and Chronic Migraine Using Spreading Depression In Vitro

Modeling Neural Immune Signaling of Episodic and Chronic Migraine Using Spreading Depression In Vitro

Published on: June 13, 2011

3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache

3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache

Published on: June 2, 2014

Determining Genetic Expression Profiles in C. elegans Using Microarray and Real-time PCR

Determining Genetic Expression Profiles in C. elegans Using Microarray and Real-time PCR

Published on: July 30, 2011

Area of Science:

Neuroscience
Genomics
Molecular Biology

Background:

Migraine attacks are distinct events, enabling study of physiological changes during and between episodes.
Gene expression is dynamic, responding to internal and external stimuli, suggesting potential migraine-specific RNA expression alterations.

Purpose of the Study:

To investigate if specific RNA expression changes occur during and outside of spontaneous migraine attacks.
To identify genes and pathways involved in migraine pathophysiology and treatment response.

Main Methods:

RNA-Sequencing, genotyping, and steroid profiling were performed on blood samples from 27 migraine patients.
Samples were collected during an attack, post-treatment, on headache-free days, and after a cold pressor test.
Differential gene expression analysis, network analysis, and integration of genomic and transcriptomic data were employed.

Main Results:

Twenty-nine differentially expressed genes were identified between 'attack' and 'after treatment' states, excluding non-migraine specific genes.
Affected pathways include fatty acid oxidation, signaling, immune responses, and ion transmembrane transport.
Integration of data revealed pathways linked to sumatriptan treatment, such as '5HT1 type receptor mediated signaling pathway'.

Conclusions:

This study uniquely examined intra-individual gene expression changes during migraine attacks.
Identified genes and pathways may play a role in migraine's underlying mechanisms and therapeutic interventions.