Related Experiment Video
Updated: Nov 9, 2025
08:38
A Strategy for the Study of IL-9-Producing Lymphoid Cells in the Nippostrongylus brasiliensis Infection Model
Published on: March 3, 2023
1.6K
IL-10-Producing ILCs: Molecular Mechanisms and Disease Relevance
Hui Sun1, Yuzhang Wu2, Yi Zhang2
1Department of Pathophysiology, Third Military Medical University, Chongqing, China.
Frontiers in Immunology
|April 16, 2021
Summary
Innate lymphoid cells (ILCs) are key sources of interleukin-10 (IL-10), crucial for immunity and inflammation. This review details how NK cells and ILC2s produce IL-10 and their role in diseases.
Area of Science:
- Immunology
- Cell Biology
Background:
- Innate lymphoid cells (ILCs), including natural killer (NK) cells and helper-like lymphoid cells, are critical for tissue homeostasis, immunity, and inflammation.
- Dysregulation of ILCs is linked to inflammatory diseases and cancers.
- Interleukin-10 (IL-10) is a pleiotropic cytokine, with ILCs identified as a significant source.
Purpose of the Study:
- To review the molecular mechanisms governing IL-10 production in NK cells and ILC2s.
- To summarize the role of IL-10-producing ILCs in various diseases.
Main Methods:
- Literature review focusing on molecular mechanisms of IL-10 production in ILCs.
- Synthesis of existing data on ILC-derived IL-10 and its disease relevance.
Main Results:
- Stable IL-10 production is primarily observed in specific NK cell subsets and ILC2s.
- ILCs utilize distinct mechanisms for IL-10 production compared to T cells.
- IL-10-producing ILCs play roles in infections, allergies, and cancers.
Conclusions:
- Understanding IL-10 regulation in ILCs is vital for disease intervention.
- IL-10-producing ILCs represent a significant area for future research in immunology and disease pathogenesis.
Related Concept Videos
01:24T Cell Types and Functions
1.7K
When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
1.7K
01:18Lymphoid Cells and Tissues
2.2K
Lymphoid cells and tissues are integral to the immune system, which is crucial in maintaining our body's defense against harmful pathogens. They form the building blocks of lymphoid organs, which include the spleen, thymus, and lymph nodes.
Lymphoid cells consist of various types of immune system cells. These include B and T lymphocytes, which are responsible for producing antibodies and killing infected cells, respectively. Dendritic cells act as messengers between the innate and adaptive...
Lymphoid cells consist of various types of immune system cells. These include B and T lymphocytes, which are responsible for producing antibodies and killing infected cells, respectively. Dendritic cells act as messengers between the innate and adaptive...
2.2K
01:22T Cell Activation and Clonal Selection
13.7K
T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...
Naive T cells that have not yet encountered an antigen express two primary CD...
13.7K
01:27Cytotoxic T Cells-mediated Immune Response
5.7K
Cytotoxic T cells are a vital component of the immune system. They have the remarkable ability to identify and target antigens on infected or abnormal cells. These antigens often originate from intracellular pathogens such as viruses or abnormal proteins cancer cells produce.
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...
5.7K