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Maternal HLA Ib Polymorphisms in Pregnancy Allo-Immunization.

Gry Persson1, Christophe Picard2,3, Gregory Marin4

  • 1Centre for Immune Regulation and Reproductive Immunology (CIRRI), Department of Clinical Biochemistry, The ReproHealth Research Consortium ZUH, Zealand University Hospital, Roskilde, Denmark.

Frontiers in Immunology
|April 16, 2021
PubMed
Summary
This summary is machine-generated.

Certain maternal HLA class Ib genes, like HLA-E*01:06, are linked to increased anti-human leukocyte antigen (HLA) antibody formation during pregnancy. Other HLA class Ib factors may promote immune tolerance.

Keywords:
HLA class IbIgG4anti-HLA alloimmunizationpregnancytolerance

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Area of Science:

  • Immunogenetics
  • Reproductive immunology
  • Transplantation immunology

Background:

  • Alloreactive anti-human leukocyte antigen (HLA) antibodies formed during pregnancy can cause transplant rejection and transfusion complications.
  • Understanding maternal genetic factors influencing allo-immunization is crucial for improving pregnancy outcomes and transfusion safety.

Purpose of the Study:

  • To identify maternal HLA class Ib genetic factors associated with anti-HLA allo-immunization during pregnancy.
  • To assess the degree of immune tolerance, estimated by IgG4 expression, in relation to these genetic factors.

Main Methods:

  • Genotyping of 86 primiparous women for HLA class Ib alleles (HLA-E, -F, -G).
  • Screening of maternal serum for anti-HLA class I and II antibodies, Donor Specific Antibody (DSA), C1q, and IgG4 concentrations.
  • Analysis of associations between maternal HLA class Ib genotypes and allo-immunization markers.

Main Results:

  • The maternal HLA-E*01:06 allele was significantly associated with a higher incidence of anti-HLA I immunization (20.0% vs. 4.8%).
  • Maternal HLA-G UTR4 and HLA-F*01:03:01 alleles were linked to low anti-HLA I complement activation (C1q).
  • HLA-G and HLA-F*01:03:01 showed significantly higher IgG4 levels, indicating a potential role in immune tolerance.

Conclusions:

  • Specific HLA class Ib alleles, including HLA-E*01:06, HLA-F*01:03, and HLA-G UTR4, are associated with allo-immunization risk during pregnancy.
  • These findings suggest a role for HLA class Ib in modulating maternal immune responses to fetal antigens.
  • Further research is warranted to elucidate the mechanisms by which these HLA class Ib alleles influence allo-immunization and tolerance.