Evaluation of Thyroid Function in Patients Hospitalized for Acute Heart Failure

Area of Science:

• Cardiology
• Endocrinology
• Internal Medicine

Background:

• Thyroid hormones (TH) are vital for maintaining cardiovascular homeostasis.
• Acute heart failure (AHF) significantly disrupts the thyroid axis.
• Understanding thyroid function's role in AHF is crucial for patient outcomes.

Purpose of the Study:

• To investigate the association between thyroid function and cardiovascular parameters in AHF patients.
• To evaluate the relationship between thyroid function and short- and long-term clinical outcomes in AHF.

Main Methods:

• Retrospective cohort study of 235 patients hospitalized for AHF (2012-2017).
• Analysis of thyroid-stimulating hormone (TSH) and free thyroxine (FT4) levels.
• Regression models used to assess associations with cardiovascular parameters and mortality (in-hospital, 30-day, long-term).

Main Results:

• Adjusted analysis showed positive association between TSH and diastolic blood pressure.
• Adjusted analysis revealed negative association between FT4 and left ventricle ejection fraction (LVEF).
• Higher FT4 levels significantly associated with increased odds of 30-day all-cause mortality in euthyroid patients.

Conclusions:

• Thyroid function parameters (TSH, FT4) correlate with blood pressure and LVEF in hospitalized AHF patients.
• Free thyroxine (FT4) may serve as a potential biomarker for short-term adverse outcomes in AHF.
• TSH and FT4 were not significant predictors of long-term mortality in this cohort.