Related Experiment Video
Updated: Nov 9, 2025
12:32
Isolation of Dendritic Cells from the Human Female Reproductive Tract for Phenotypical and Functional Studies
Published on: March 13, 2018
6.7K
Localized and Systemic Immune Response in Human Reproductive Tract
Rajendra Gudisa1, Kapil Goyal1, Parakriti Gupta1
1Department of Virology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
Frontiers in Cellular and Infection Microbiology
|April 16, 2021
Summary
Sexually transmitted infections (STIs) are a global health issue. Understanding their immunopathology is key to developing new treatments and vaccines for these widespread infections.
Area of Science:
- Immunology
- Infectious Diseases
- Microbiology
Background:
- Sexually transmitted infections (STIs) cause significant global morbidity and mortality.
- STIs are under-reported, with many reaching epidemic proportions.
- The unraveled immunopathology of STIs hinders vaccine development.
Purpose of the Study:
- To understand the immunopathology of sexually transmitted infections.
- To identify potential targets for immunization against STIs.
- To explore therapeutic strategies by targeting host-pathogen interactions.
Main Methods:
- Investigating the interplay between innate immune defenses, resident microbiota, and mucosal immune responses.
- Characterizing pathogen-specific antibodies against immunogenic molecules.
Main Results:
- The complex interactions within the immune system are crucial for STI pathogenesis.
- Identifying specific antibodies may reveal protective effects.
Conclusions:
- Deciphering the immunopathology of STIs is vital for controlling their spread.
- Targeting immune interactions offers potential therapeutic avenues.
- Pathogen-specific antibodies could be key to developing effective STI vaccines.
Related Concept Videos
01:29Immune Response Against Viral Pathogens
1.2K
The immune system's response to viral infections is a complex and coordinated process involving natural killer (NK) cells, T cell-mediated responses, and antibody-mediated responses.
NK Cells
NK cells are a crucial part of our innate immune system, acting as the first line of defense against viral infections. These cells can recognize and kill infected cells without prior exposure to the virus, effectively slowing down the spread of infection. Additionally, NK cells produce proinflammatory...
NK Cells
NK cells are a crucial part of our innate immune system, acting as the first line of defense against viral infections. These cells can recognize and kill infected cells without prior exposure to the virus, effectively slowing down the spread of infection. Additionally, NK cells produce proinflammatory...
1.2K
01:22Development of Immunocompetence
561
The initiation of cell-mediated immunity can be observed as early as the third month of fetal growth, with active antibody-mediated immunity following approximately one month later.
The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
Subsequent T...
The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
Subsequent T...
561
01:40Cell-mediated Immune Responses
79.0K
Overview
79.0K
01:21Introduction to Innate and Adaptive Immunity
6.7K
The human immune system is a complex defense mechanism that protects the body from harmful pathogens and foreign substances. It comprises two crucial components: innate and adaptive immunity.
Innate immunity is the body's natural, nonspecific defense system that acts quickly to protect against pathogens. It incorporates physical barriers like skin and mucous membranes and cellular elements such as phagocytes and natural killer cells. This part of our immune system provides an immediate,...
Innate immunity is the body's natural, nonspecific defense system that acts quickly to protect against pathogens. It incorporates physical barriers like skin and mucous membranes and cellular elements such as phagocytes and natural killer cells. This part of our immune system provides an immediate,...
6.7K
01:36Humoral Immune Responses
79.6K
Overview
79.6K
01:15Transcytosis of IgG
3.6K
Transcytosis is the process in which molecules are internalized by endocytosis, transported across the cell, and released through exocytosis from the opposite end of the cell. Molecules such as insulin, immunoglobulins, and certain nutrients are transferred through the recycling endosomes by recycling and transcytosis.
IgG molecules from a mother undergo transcytosis starting around 13 weeks of gestation. The amount of IgG transferred and entering the fetal blood circulation increases with...
IgG molecules from a mother undergo transcytosis starting around 13 weeks of gestation. The amount of IgG transferred and entering the fetal blood circulation increases with...
3.6K