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Updated: Nov 9, 2025

Next Generation Sequencing for the Detection of Actionable Mutations in Solid and Liquid Tumors
Published on: September 20, 2016
Metabolic subtypes of clear cell renal cell carcinoma defined by tobacco smoking
Maria F Czyzyk-Krzeska1,2, Jarek Meller3,4,5, Julio A Landero Figueroa6
1Department of Cancer Biology, University of Cincinnati, Cincinnati, OH, USA.
Abstract:
Tobacco smoking (TS) results in reprogramming of major metabolic pathways, including glycolysis, the citric acid (TCA) cycle, oxidative phosphorylation, and metabolism of aspartate, glutamate and glutamine in clear cell renal cell carcinoma (ccRCC). TS alters the distribution and activities of cadmium, arsenic and copper in a manner mechanistically supporting metabolic remodeling. Alterations in metabolism and metal distribution identify new actionable targets for treatment of ccRCC.

