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Approach to Intestinal Failure in Children

Danielle Wendel1, Conrad R Cole2, Valeria C Cohran3

  • 1Division of Gastroenterology and Hepatology, Seattle Children's Hospital, University of Washington School of Medicine, Seattle, WA, USA. danielle.wendel@seattlechildrens.org.

Current Gastroenterology Reports
|April 16, 2021
PubMed

Insights

Recent advances in pediatric intestinal failure care improve outcomes and reduce the need for intestinal transplant. New therapies, including hormone replacement, promote intestinal adaptation and enhance patient recovery.

Area of Science:

  • Pediatric Gastroenterology
  • Intestinal Rehabilitation
  • Surgical Innovation

Background:

  • Pediatric intestinal failure presents complex challenges requiring specialized management.
  • Effective care is crucial to prevent severe complications and improve patient outcomes.

Purpose of the Study:

  • To review recent evidence and advancements in the care of children with intestinal failure.
  • To highlight strategies promoting intestinal adaptation and reducing transplant dependency.

Main Methods:

  • Review of current medical and surgical management techniques.
  • Analysis of recent therapeutic innovations in intestinal rehabilitation.

Main Results:

  • Multidisciplinary teams achieve enteral autonomy (EA) through advanced care.
  • Progress in lipid management, liver disease prevention, and infection control is noted.
  • New hormone analogue therapies show promise in promoting intestinal adaptation, decreasing transplant rates.

Conclusions:

  • Recent advancements significantly decrease morbidity, mortality, and the need for intestinal transplantation in pediatric patients.
  • Enteroendocrine hormone replacement represents a promising therapeutic frontier.
Abstract

Keywords:
Central venous accessIntestinal failure associated liver diseaseIntestinal rehabilitationIntestinal transplantParenteral nutritionTeduglutide

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