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Sibylle Schliemann1, Maren Müller2, Martina Stadeler2

  • 1Klinik für Hautkrankheiten, Universitätsklinikum Jena.

Journal Der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG
|April 16, 2021
PubMed
Summary
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Six commercial skin protectants were evaluated for their protective effects against sodium lauryl sulfate (SLS) induced irritation. Significant differences in efficacy were found, allowing for product categorization to aid user selection of effective skin protection.

Area of Science:

  • Dermatology
  • Occupational Health
  • Cosmetic Science

Context:

  • Occupational skin diseases are a significant concern, with skin protectants used for prevention.
  • Many products are marketed for wet work, but objective quality assessments are lacking.
  • Comparative efficacy studies are needed to guide user selection of skin protectants.

Purpose:

  • To objectively compare the protective efficacy of six commercial skin protectants.
  • To evaluate the pre-exposure protective effect against sodium lauryl sulfate (SLS) induced irritation.
  • To assess differences using skin physiological methods, including transepidermal water loss (TEWL).

Summary:

  • A double-blind, randomized, controlled in vivo study assessed six commercial skin protectants.

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  • The study used a repetitive irritation model with SLS to induce contact eczema.
  • Efficacy was measured by transepidermal water loss (TEWL), corneometry, and visual scoring.

    • Impact:

    • The study revealed significant differences in the protective efficacy of the evaluated skin protectants.
    • These findings allow for a categorization of products based on their effectiveness.
    • This categorization can assist users in selecting appropriate protective preparations for occupational skin health.