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Related Experiment Video

Updated: Nov 9, 2025

Robot-assisted Total Mesorectal Excision and Lateral Pelvic Lymph Node Dissection for Locally Advanced Middle-low Rectal Cancer
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Pelvic lymph node dissection in high-risk prostate cancer.

Luciano Haiquel1, Xavier Cathelineau2, Rafael Sanchez-Salas2

  • 1Department of Urology, Sanatorio Las Lomas de San Isidro, Buenos Aires, Argentina.

International Braz J Urol : Official Journal of the Brazilian Society of Urology
|April 16, 2021
PubMed
Summary

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Canadian Urological Association journal = Journal de l'Association des urologues du Canada·2026

Pelvic lymph node dissection (PLND) in prostate cancer (PCa) staging is accurate but its therapeutic benefit remains unclear. Identifying high-risk PCa patients who benefit from extended PLND requires further research.

Area of Science:

  • Urology
  • Oncology
  • Surgical Oncology

Background:

  • The therapeutic value of pelvic lymph node dissection (PLND) in prostate cancer (PCa) is not well-established due to a lack of randomized controlled trials.
  • High-risk PCa frequently metastasizes, making lymph node status a critical factor.

Purpose of the Study:

  • To critically review the therapeutic benefits of PLND in patients with high-risk localized PCa.
  • To evaluate the role of PLND in staging and treatment of prostate cancer.

Main Methods:

  • A comprehensive literature search was conducted using PubMed, Cochrane, and Medline databases.
  • Articles were reviewed focusing on diagnostic imaging, sentinel lymph node dissection, PLND extension, survival impact, node-positive disease, and surgical risks.
Keywords:
LymphLymph Node ExcisionProstate cancer, familial [Supplementary Concept]

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Main Results:

  • Extended PLND is the most accurate method for staging lymph node disease in high-risk PCa, despite advances in imaging and sentinel node techniques.
  • While potentially beneficial for staging and therapeutic intent in selected patients, extended PLND increases surgical complexity and costs.
  • Controversy exists regarding the therapeutic benefit of PLND, especially in cases with significant lymph node burden.

Conclusions:

  • The definitive impact of PLND on biochemical recurrence and prostate cancer survival remains uncertain.
  • Accurate patient selection is crucial for maximizing the benefits of extended PLND.
  • Prospective randomized studies are necessary to elucidate the precise role of PLND in high-risk, pelvis-confined PCa.