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Diagnosis and treatment of HCV heart diseases

Mohammad Haykal1, Akira Matsumori2, Ahmed Saleh1

  • 1Cardiovascular and Ultrasonography Research Unit (CURU), Research Institute of Ophthalmology (RIO), Cairo, Egypt.

Expert Review of Cardiovascular Therapy
|April 16, 2021
PubMed

Insights

Hepatitis C virus (HCV) infection is a significant, often unrecognized, cause of diverse heart conditions. Early diagnosis is crucial for effective treatment of these HCV-related cardiovascular diseases.

Area of Science:

  • Cardiology
  • Infectious Diseases
  • Hepatology

Background:

  • Hepatitis C virus (HCV) infection is linked to various unexplained heart diseases and myocardial injury.
  • A high prevalence of HCV is observed in patients with hypertrophic cardiomyopathy, dilated cardiomyopathy, arrhythmogenic right ventricular dysplasia/cardiomyopathy, and myocarditis.
  • HCV infection is associated with arrhythmias, conduction disturbances, and QT prolongation.

Purpose of the Study:

  • To evaluate the evidence linking HCV to various cardiovascular diseases.
  • To discuss the pathogenesis of HCV-induced cardiovascular disorders.
  • To explore the role of HCV in the development of diabetes and atherosclerosis.

Main Methods:

  • Review of existing evidence on HCV and cardiovascular diseases.
  • Discussion of proposed pathogenetic mechanisms.
  • Evaluation of recent hypotheses regarding HCV targets.

Main Results:

  • HCV is implicated as a cause of numerous heart conditions globally.
  • These HCV-related heart diseases are frequently underdiagnosed by cardiologists.
  • Recognition and diagnosis are essential for timely intervention.

Conclusions:

  • HCV infection contributes to a wide spectrum of cardiovascular diseases.
  • The diverse clinical manifestations may stem from HCV targeting leukocytes.
  • Further research and clinical awareness are needed for accurate diagnosis and treatment.
Abstract

Keywords:
Arrhythmiasatherosclerosiscardiomyopathyhepatitis C virusimmunityinflammationleukocytesmyocarditispericarditistherapy

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