Related Experiment Video
Updated: Nov 9, 2025
05:58
Preparation of Single-cell Suspensions for Cytofluorimetric Analysis from Different Mouse Skin Regions
Published on: April 20, 2016
19.0K
Neu(ronal) custodians of cutaneous immunity
Kody Paul Mansfield1, Shruti Naik1
1Department of Pathology, Department of Medicine, Ronald O. Perelman Department of Dermatology and Perlmutter Cancer Center, New York University Langone Health, 550 First Avenue, New York, NY 10016, USA.
Cell
|April 16, 2021
Summary
Skin Langerhans cells (LCs) maintain immune balance by regulating sensory neurons and mast cells (MCs). This study reveals an anti-inflammatory circuit involving LCs, neurons, and MCs, crucial for skin homeostasis.
Area of Science:
- Immunology
- Neuroscience
- Dermatology
Background:
- Sensory neurons are implicated as key drivers of skin inflammation.
- Understanding skin immune homeostasis requires investigating cellular interactions.
Purpose of the Study:
- To define the anti-inflammatory circuit involving Langerhans cells (LCs), neurons, and mast cells (MCs).
- To elucidate the role of LCs in maintaining skin immune homeostasis.
Main Methods:
- Investigated the interaction between LCs, nonpeptidergic neurons, and MCs in skin.
- Utilized molecular and cellular techniques to define the circuit components and mechanisms.
Main Results:
- Defined an anti-inflammatory LC-neuron-MC circuit essential for skin immune homeostasis.
- Demonstrated that LCs maintain innervation of MrgprD+ nonpeptidergic neurons.
- Showed that these neurons restrain MC activation through glutamate secretion.
Conclusions:
- LCs play a critical role in regulating skin inflammation by modulating neuronal activity.
- The identified circuit offers a novel target for treating inflammatory skin conditions.
Related Concept Videos
01:24Cells of the Epidermis
6.0K
The epidermis is made of four or five layers of epithelial cells, depending on its location in the body. From deep to superficial, these layers are the stratum basale, stratum spinosum, stratum granulosum, stratum lucidum, and stratum corneum.
The cells in all these layers except the stratum basale are called keratinocytes, a type of cell that manufactures and stores the protein keratin. The keratinocytes in the stratum corneum are dead and regularly slough away, being replaced by cells from...
The cells in all these layers except the stratum basale are called keratinocytes, a type of cell that manufactures and stores the protein keratin. The keratinocytes in the stratum corneum are dead and regularly slough away, being replaced by cells from...
6.0K
01:16Sensory Functions of the Skin
6.8K
The skin is the largest organ of the human body and plays a crucial role in our sensory perception. It contains a vast network of sensory receptors that contribute to the skin's protective function by perceiving physical, biological, and environmental cues and generating relevant responses.
There are two main categories of receptors on the skin: capsulated and non-capsulated. The non-capsulated ones are mainly the pain receptors. The capsulated ones can be further categorized based on the...
There are two main categories of receptors on the skin: capsulated and non-capsulated. The non-capsulated ones are mainly the pain receptors. The capsulated ones can be further categorized based on the...
6.8K
01:23Cells of the Adaptive Immune Response
7.3K
The T and B lymphocytes of the adaptive immune system develop from common lymphoid progenitor cells in the bone marrow. These progenitors give rise to precursors that eventually develop into both T and B lymphocytes. As these precursors mature, they gain the ability to detect and respond to foreign antigens in the body, a process known as immunocompetence. Additionally, these precursors acquire self-tolerance, a process that ensures they do not react to self-antigens. This intricate system...
7.3K
01:11Papillary Dermis
4.7K
Dermis
The dermis might be considered the "core" of the integumentary system, as distinct from the epidermis and hypodermis. It contains blood and lymph vessels, nerves, and other structures, such as hair follicles and sweat glands. The dermis is made of two layers of connective tissue that comprise an interconnected mesh of elastin and collagenous fibers, produced by fibroblasts.
Papillary Layer
The papillary layer is made of loose, areolar connective tissue, which means the collagen...
The dermis might be considered the "core" of the integumentary system, as distinct from the epidermis and hypodermis. It contains blood and lymph vessels, nerves, and other structures, such as hair follicles and sweat glands. The dermis is made of two layers of connective tissue that comprise an interconnected mesh of elastin and collagenous fibers, produced by fibroblasts.
Papillary Layer
The papillary layer is made of loose, areolar connective tissue, which means the collagen...
4.7K
01:28Cells of the Innate Immune Response
7.5K
The innate immune response is an immediate and non-specific response against pathogens, acting swiftly to prevent the spread of infections. The primary cells involved in this response are phagocytes and natural killer (NK) cells.
Phagocytes
Phagocytes police the peripheral tissues by removing cellular debris and responding to the invasion of foreign substances or pathogens. Many phagocytes attack and remove microorganisms even before lymphocytes detect them. The human body has two general...
Phagocytes
Phagocytes police the peripheral tissues by removing cellular debris and responding to the invasion of foreign substances or pathogens. Many phagocytes attack and remove microorganisms even before lymphocytes detect them. The human body has two general...
7.5K
01:40Cell-mediated Immune Responses
79.0K
Overview
79.0K