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Hempseed (Cannabis sativa) offers effective alternative over statins in ameliorating hypercholesterolemia associated

Simarpreet Kaur1, Ayushi Garg1, Naveen Kaushal1

  • 1Department of Biophysics, Panjab University, Chandigarh 160014, India.

Clinical Biochemistry
|April 16, 2021
PubMed

Insights

Hempseed lipid extract (HEMP) shows therapeutic potential against hypercholesterolemia-associated kidney damage, offering a safer alternative to statins by improving lipid profiles and reducing inflammation.

Area of Science:

  • Biochemistry
  • Pharmacology
  • Nephrology

Background:

  • Hypercholesterolemia (HC) is linked to kidney damage.
  • Statins, used for HC, can cause renal side effects.
  • Natural alternatives for HC management are being explored.

Purpose of the Study:

  • To evaluate hempseed lipid extract (HEMP) for anti-inflammatory and redox effects against HC-induced renal damage.
  • To compare HEMP's efficacy and safety with statins (Simvastatin) in a rat model.

Main Methods:

  • HEMP was prepared and administered to rats with high-fat diet (HFD)-induced HC.
  • Effects on lipid profiles, renal function, oxidative stress, and inflammation were assessed.
  • HEMP's impact on lipid metabolism mediators (APO-B/E) was analyzed.

Main Results:

  • HEMP improved lipid profiles and renal morphology, showing safety comparable to Simvastatin.
  • HEMP modulated renal histoarchitecture, reduced oxidative stress, and influenced inflammatory pathways.
  • HEMP activated resolution pathways, mitigating HC-associated renal insults.

Conclusions:

  • HEMP demonstrates significant ameliorative and therapeutic potential for hypercholesterolemia-associated nephropathies.
  • HEMP offers a promising natural strategy for managing HC and its renal complications.
  • HEMP's safety profile suggests it as a viable alternative to statins.

Keywords:
High-fat dietHypercholesterolemiaInflammationOxidative stressRenal damage

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