Facilitating target search in polymer networks: Effects of target size and mixed one-dimensional and...

We theoretically investigate the problem of diffusive target search and mean first passage times (MFPTs) of a tracer in a three-dimensional (3D) polymer network with a particular focus on the effects of combined one-dimensional (1D) diffusion along the polymer chains and 3D diffusion within the network. For this, we employ computer simulations as well as limiting theories of a single diffusive tracer searching for a spherical target fixed at a cross-link of a homogeneous 3D cubic lattice network. The free parameters are the target size, the ratio of the 1D and 3D friction constants, and the transition probabilities between bound and unbound states. For a very strongly bound tracer on the chains, the expected predominant set of 1D lattice diffusion (LD) is found. The MFPT in the LD process significantly depends on the target size, yielding two distinct scaling behaviors for target sizes smaller and larger than the network mesh size, respectively. In the limit of a pointlike target, the LD search becomes a random walk process on the lattice, which recovers the analytical solution for the MFPT previously reported by S. Condamin, O. Bénichou, and M. Moreau [Phys. Rev. Lett. 95, 260601 (2005)PRLTAO0031-900710.1103/PhysRevLett.95.260601]. For the very weakly bound tracer, the expected 3D free diffusion (FD) dominates, extrapolating to the well-known Smoluchowski limit. A critical target size is found above which the MFPT in the FD process is faster than in the LD process. For intermediate binding, i.e., a combination of LD and FD processes, the target search time can be minimized for an optimal range of target sizes and partitions between FD and LD, for which the MFPTs are substantially faster when compared to the limiting FD or LD processes. Our study may provide a theoretical basis to better understand and predict search and reaction processes in complex structured materials, thereby contributing to practical applications such as designing nanoreactors where catalytic targets are immobilized in polymer networks.