Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Mismatch Repair01:20

Mismatch Repair

5.7K
Organisms are capable of detecting and fixing nucleotide mismatches that occur during DNA replication. This sophisticated process requires identifying the new strand and replacing the erroneous bases with correct nucleotides. Mismatch repair is coordinated by many proteins in both prokaryotes and eukaryotes.
The Mutator Protein Family Plays a Key Role in DNA Mismatch Repair
The human genome has more than 3 billion base pairs of DNA per cell. Prior to cell division, that vast amount of genetic...
5.7K
Mismatch Repair01:36

Mismatch Repair

42.4K
Overview
42.4K
Mutations01:39

Mutations

89.8K
Overview
89.8K
Mutations01:35

Mutations

41.7K
Mutations are changes in the sequence of DNA. These changes can occur spontaneously or they can be induced by exposure to environmental factors. Mutations can be characterized in a number of different ways: whether and how they alter the amino acid sequence of the protein, whether they occur over a small or large area of DNA, and whether they occur in somatic cells or germline cells.
Chromosomal Alterations Are Large-Scale Mutations
While point mutations are changes in a single nucleotide in...
41.7K
Point and Frameshift Mutations01:30

Point and Frameshift Mutations

413
Point mutations are genetic alterations involving the change of a single nucleotide base pair in DNA. Depending on how the alteration affects protein synthesis, they can lead to various consequences.Point mutations fall into the following types:Silent mutations occur when a nucleotide change does not alter the amino acid sequence due to the redundancy of the genetic code. For instance, changing ACC to ACA still encodes threonine, leaving the protein function unaffected. This occurs because...
413
Spontaneous and Induced Mutations01:30

Spontaneous and Induced Mutations

496
Spontaneous mutations arise infrequently during DNA replication due to errors in the process. A key factor behind these errors is tautomeric shifts in nitrogenous bases, where bases transition from keto to enol forms or amino to imino forms. This shift can alter base-pairing rules, leading to mutations. Additionally, reactive oxygen species (ROS) arising from aerobic metabolism can damage DNA, resulting in depurination (loss of a purine base) or depyrimidination (loss of a pyrimidine base).
496

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Parrondo's paradox as a framework for strategy switching and collective intelligence in complex systems Reply to comments on "Parrondo's paradox reveals counterintuitive wins in biology and decision making in society".

Physics of life reviews·2026
Same author

Adaptive Prescribed-Time Dynamic Self-Triggered Time-Varying Bipartite Formation Control for Uncertain Nonlinear Multiagent Systems With Actuator Faults.

IEEE transactions on cybernetics·2026
Same author

Prescribed performance collision-free control for bearing-constrained unmanned aerial vehicle.

ISA transactions·2025
Same author

Geometric phase in the Crow-Kimura model of molecular evolution on dynamic environments.

Physical review. E·2025
Same author

Thermodynamic selection: The role of entropy waste elimination in evolution.

Physical review. E·2025
Same author

ZO-1/Tjp1 and ZO-2/Tjp2 deletion in retinal pigment epithelium causes progressive retinal degeneration.

iScience·2025
Same journal

Erratum: Low-dimensional model for adaptive networks of spiking neurons [Phys. Rev. E 111, 014422 (2025)].

Physical review. E·2026
Same journal

Disentangling the effects of many-body forces on depletion interactions.

Physical review. E·2026
Same journal

Charge transport and mode transition in dual-energy electron beam diodes.

Physical review. E·2026
Same journal

Optimization of multisite reactions in complex compartmentalized media.

Physical review. E·2026
Same journal

Origin of geometric cohesion in nonconvex granular materials: Interplay between interdigitation and rotational constraints enhancing frictional stability.

Physical review. E·2026
Same journal

Interaction of walkers with a standing Faraday wave.

Physical review. E·2026
See all related articles

Related Experiment Video

Updated: Nov 9, 2025

Following the Dynamics of Structural Variants in Experimentally Evolved Populations
04:52

Following the Dynamics of Structural Variants in Experimentally Evolved Populations

Published on: February 3, 2023

1.1K

Weak mixed phase in the mutator model.

David B Saakian1,2, Kang Hao Cheong3

  • 1Laboratory of Applied Physics, Advanced Institute of Materials Science, Ton Duc Thang University, Ho Chi Minh City, Vietnam.

Physical Review. E
|April 17, 2021
PubMed
Summary
This summary is machine-generated.

This study introduces a new phase in the mutator model, characterized by a low fraction of wild types despite mixed-phase fitness. This finding advances our understanding of evolutionary dynamics and genome stability.

More Related Videos

Author Spotlight: Enhanced Isolation of Interaction-Null Mutants in Yeast
02:44

Author Spotlight: Enhanced Isolation of Interaction-Null Mutants in Yeast

Published on: December 29, 2023

697
An Introduction to Worm Lab: from Culturing Worms to Mutagenesis
10:44

An Introduction to Worm Lab: from Culturing Worms to Mutagenesis

Published on: January 11, 2011

35.2K

Related Experiment Videos

Last Updated: Nov 9, 2025

Following the Dynamics of Structural Variants in Experimentally Evolved Populations
04:52

Following the Dynamics of Structural Variants in Experimentally Evolved Populations

Published on: February 3, 2023

1.1K
Author Spotlight: Enhanced Isolation of Interaction-Null Mutants in Yeast
02:44

Author Spotlight: Enhanced Isolation of Interaction-Null Mutants in Yeast

Published on: December 29, 2023

697
An Introduction to Worm Lab: from Culturing Worms to Mutagenesis
10:44

An Introduction to Worm Lab: from Culturing Worms to Mutagenesis

Published on: January 11, 2011

35.2K

Area of Science:

  • Evolutionary biology
  • Theoretical population genetics
  • Genomics

Background:

  • The mutator model describes the evolution of populations with differing mutation rates.
  • Understanding the dynamics of wild-type and mutator-type frequencies is crucial for evolutionary theory.

Purpose of the Study:

  • To analyze the mutator model with unidirectional wild-type to mutator transitions.
  • To derive exact expressions for the fraction of mutator types and genomic mutation surpluses.
  • To identify and characterize the phase structure of the mutator model.

Main Methods:

  • Mathematical modeling of the mutator model.
  • Calculation of population fractions and mean number of mutations (surpluses).
  • Phase diagram analysis based on genome length and fitness parameters.

Main Results:

  • Exact derivation of mutator fraction and surpluses for wild and mutator types.
  • Identification of three distinct phases: mixed, mutator, and a novel phase with exponentially small wild-type fraction.
  • Characterization of a new phase exhibiting mixed-phase mean fitness but rare wild types.

Conclusions:

  • The study reveals a previously unknown phase in the mutator model, expanding our understanding of evolutionary trajectories.
  • Exact derivations provide a quantitative basis for analyzing genomic mutation accumulation.
  • The identified phase transition point has implications for genome stability and the evolution of mutator strains.