Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The Early Detection of Malignant Transformation of Potentially Malignant Disorders: Oral Lichen Planus.

Cancers·2025
Same author

Evaluation of Static DNA Ploidy Analysis Using Conventional Brush Biopsy-Based Cytology Samples as an Adjuvant Diagnostic Tool for the Detection of a Malignant Transformation in Potentially Oral Malignant Diseases: A Prospective Study.

Cancers·2022
Same author

Correction to: Retrospective evaluation of the oral brush biopsy in daily dental routine - an effective way of early cancer detection.

Clinical oral investigations·2022
Same author

Retrospective evaluation of the oral brush biopsy in daily dental routine - an effective way of early cancer detection.

Clinical oral investigations·2022
Same author

Evaluation of the Accuracy of Liquid-Based Oral Brush Cytology in Screening for Oral Squamous Cell Carcinoma.

Cancers·2019
Same author

Bacterial Colonization and Tissue Compatibility of Denture Base Resins.

Dentistry journal·2018

Related Experiment Video

Updated: Nov 9, 2025

Absorbent Microbiopsy Sampling and RNA Extraction for Minimally Invasive, Simultaneous Blood and Skin Analysis
06:18

Absorbent Microbiopsy Sampling and RNA Extraction for Minimally Invasive, Simultaneous Blood and Skin Analysis

Published on: February 21, 2019

10.2K

Comparison between two cell collecting methods for liquid-based brush biopsies: a consecutive and retrospective

Kristin Gaida1, Lena Deuerling1, Heinrich Neumann2

  • 1Department of Oral, Maxillofacial and Facial Plastic Surgery, Section of Clinical and Experimental Oral Medicine, Leipzig University Hospital, Liebigstraße 10-14, 04103, Leipzig, Germany.

BMC Oral Health
|April 17, 2021
PubMed
Summary

The rigid brush offers higher specificity for detecting oral cancer than the nylon brush, despite similar sensitivity. This cell collector is also quicker and less stressful for patients during oral brush biopsies.

Keywords:
Brush biopsyLiquid-based cytologyOral cancerSquamous cell carcinoma

More Related Videos

Establishment of a Clinic-based Biorepository
07:50

Establishment of a Clinic-based Biorepository

Published on: May 29, 2017

6.7K
Automatic Separation and Collection of Cancer-Related Substances from Clinical Samples
08:49

Automatic Separation and Collection of Cancer-Related Substances from Clinical Samples

Published on: January 13, 2023

2.1K

Related Experiment Videos

Last Updated: Nov 9, 2025

Absorbent Microbiopsy Sampling and RNA Extraction for Minimally Invasive, Simultaneous Blood and Skin Analysis
06:18

Absorbent Microbiopsy Sampling and RNA Extraction for Minimally Invasive, Simultaneous Blood and Skin Analysis

Published on: February 21, 2019

10.2K
Establishment of a Clinic-based Biorepository
07:50

Establishment of a Clinic-based Biorepository

Published on: May 29, 2017

6.7K
Automatic Separation and Collection of Cancer-Related Substances from Clinical Samples
08:49

Automatic Separation and Collection of Cancer-Related Substances from Clinical Samples

Published on: January 13, 2023

2.1K

Area of Science:

  • Oral pathology
  • Cytopathology
  • Biomedical engineering

Background:

  • Oral brush biopsies are crucial for diagnosing oral lesions.
  • Comparing cell collectors aids in optimizing diagnostic accuracy.
  • Liquid-based cytology enhances cellular sample analysis.

Purpose of the Study:

  • To compare the diagnostic accuracy of the Orcellex Brush (rigid) and Cytobrush GT (nylon) for oral malignancy detection.
  • To evaluate the efficiency and patient experience associated with each cell collector.
  • To assess the clinical expenditure of different brush types.

Main Methods:

  • A retrospective study of 2018 patients with oral lesions from 2009-2018.
  • Comparison of nylon brush (666 cases) and rigid brush (1352 cases) in liquid-based cytology.
  • Cytological results categorized as negative or positive for malignancy against histological diagnoses.

Main Results:

  • Both brushes showed high sensitivity, with the rigid brush at 95.6% and nylon brush at 93.8%.
  • The rigid brush achieved higher specificity (84.9%) compared to the nylon brush (94.2%).
  • The rigid brush was 4x faster and yielded more cells with less patient stress.

Conclusions:

  • The rigid brush demonstrates superior specificity in oral brush biopsies for malignancy detection.
  • While both collectors are sensitive, the rigid brush offers better specificity and efficiency.
  • Further methods like DNA image cytometry may enhance specificity; the rigid brush is recommended for its effectiveness and patient comfort.